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METTL21C methyltransferase 21C, AARS1 lysine [ Homo sapiens (human) ]

Gene ID: 196541, updated on 25-Nov-2021

Summary

Official Symbol
METTL21Cprovided by HGNC
Official Full Name
methyltransferase 21C, AARS1 lysineprovided by HGNC
Primary source
HGNC:HGNC:33717
See related
Ensembl:ENSG00000139780 MIM:615259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C13orf39
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See METTL21C in Genome Data Viewer
Location:
13q33.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (102678782..102704311, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (103338097..103347394, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 14 Neighboring gene FGF14 antisense RNA 2 Neighboring gene uncharacterized LOC107984588 Neighboring gene tripeptidyl peptidase 2 Neighboring gene uncharacterized LOC105370337 Neighboring gene coiled-coil domain containing 168 Neighboring gene testis expressed 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein-lysine methyltransferase METTL21C
Names
methyltransferase like 21C
methyltransferase-like protein 21C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010977.3NP_001010977.1  protein-lysine methyltransferase METTL21C

    See identical proteins and their annotated locations for NP_001010977.1

    Status: VALIDATED

    Source sequence(s)
    AL158063
    Consensus CDS
    CCDS32003.1
    UniProtKB/Swiss-Prot
    Q5VZV1
    Related
    ENSP00000267273.5, ENST00000267273.7
    Conserved Domains (1) summary
    cl17173
    Location:73239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    102678782..102704311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020408.2XP_016875897.1  protein-lysine methyltransferase METTL21C isoform X1

    UniProtKB/Swiss-Prot
    Q5VZV1
    Conserved Domains (1) summary
    cl17173
    Location:73239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_017020407.2XP_016875896.1  protein-lysine methyltransferase METTL21C isoform X1

    UniProtKB/Swiss-Prot
    Q5VZV1
    Conserved Domains (1) summary
    cl17173
    Location:73239
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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