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DCP1B decapping mRNA 1B [ Homo sapiens (human) ]

Gene ID: 196513, updated on 21-Dec-2019

Summary

Official Symbol
DCP1Bprovided by HGNC
Official Full Name
decapping mRNA 1Bprovided by HGNC
Primary source
HGNC:HGNC:24451
See related
Ensembl:ENSG00000151065 MIM:609843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCP1
Summary
This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Broad expression in testis (RPKM 7.9), endometrium (RPKM 5.4) and 25 other tissues See more
Orthologs

Genomic context

See DCP1B in Genome Data Viewer
Location:
12p13.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (1941591..2004535, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (2055214..2113677, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 4 Neighboring gene uncharacterized LOC112268103 Neighboring gene long intergenic non-protein coding RNA 940 Neighboring gene CACNA1C intronic transcript 1 Neighboring gene calcium voltage-gated channel subunit alpha1 C Neighboring gene CACNA1C intronic transcript 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with DCP1 in a miRNA- and P-body-independent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mRNA-decapping enzyme 1B
Names
DCP1 decapping enzyme homolog B
decapping enzyme hDcp1b
NP_001306221.1
NP_689853.3
XP_011519229.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319292.2NP_001306221.1  mRNA-decapping enzyme 1B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' coding exons and extends past a splice site used in variant 1, resulting in a different 3' coding region and 3' UTR. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC005342, AK301109, BM544996, BQ773904, BU930253, DC425587
    Consensus CDS
    CCDS81651.1
    UniProtKB/TrEMBL
    B4DVJ6
    Related
    ENSP00000482714.1, ENST00000535873.2
    Conserved Domains (1) summary
    cd09804
    Location:16108
    Dcp1; mRNA decapping enzyme 1 (Dcp1)
  2. NM_152640.5NP_689853.3  mRNA-decapping enzyme 1B isoform 1

    See identical proteins and their annotated locations for NP_689853.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK299203, AW204088, AY146652, BC015368
    Consensus CDS
    CCDS31727.1
    UniProtKB/Swiss-Prot
    Q8IZD4
    Related
    ENSP00000280665.6, ENST00000280665.11
    Conserved Domains (2) summary
    cd09804
    Location:16131
    Dcp1; mRNA decapping enzyme 1 (Dcp1)
    pfam16741
    Location:574615
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

RNA

  1. NR_135060.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate internal exon and differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005342, AK299203, DC425587
    Related
    ENST00000543381.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    1941591..2004535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520927.3XP_011519229.1  mRNA-decapping enzyme 1B isoform X1

    See identical proteins and their annotated locations for XP_011519229.1

    UniProtKB/Swiss-Prot
    Q8IZD4
    Conserved Domains (2) summary
    pfam16741
    Location:472513
    mRNA_decap_C; mRNA-decapping enzyme C-terminus
    cl17171
    Location:629
    PH-like; Pleckstrin homology-like domain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654718.1 Reference GRCh38.p13 PATCHES

    Range
    283735..346679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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