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Rbl2 RB transcriptional corepressor like 2 [ Mus musculus (house mouse) ]

Gene ID: 19651, updated on 13-Aug-2019

Summary

Official Symbol
Rbl2provided by MGI
Official Full Name
RB transcriptional corepressor like 2provided by MGI
Primary source
MGI:MGI:105085
See related
Ensembl:ENSMUSG00000031666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rb2; PRB2; p130; RBR-2
Expression
Ubiquitous expression in testis adult (RPKM 14.0), bladder adult (RPKM 10.1) and 28 other tissues See more
Orthologs

Genomic context

See Rbl2 in Genome Data Viewer
Location:
8 C4; 8 44.25 cM
Exon count:
22
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (91070057..91123844)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (93593993..93647743)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1483 Neighboring gene chromodomain helicase DNA binding protein 9 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene predicted gene, 39221 Neighboring gene thymoma viral proto-oncogene 1 interacting protein Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene predicted gene, 36243 Neighboring gene Rpgrip1-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Adipogenesis genes, organism-specific biosystem (from WikiPathways)
    Adipogenesis genes, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
    Cell cycle signaling pathway, organism-specific biosystem
    Cell cycle signaling pathway
  • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
    Cyclin D associated events in G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • G0 and Early G1, organism-specific biosystem (from REACTOME)
    G0 and Early G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • G1 Phase, organism-specific biosystem (from REACTOME)
    G1 Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
  • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
    Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II activating transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
retinoblastoma-like protein 2
Names
130 kDa retinoblastoma-associated protein
retinoblastoma-like 2
retinoblastoma-related protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282000.1NP_001268929.1  retinoblastoma-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI323872, AK160027, BY270001, CF736271
    Consensus CDS
    CCDS85581.1
    UniProtKB/Swiss-Prot
    Q64700
    UniProtKB/TrEMBL
    A0A1B0GRM0
    Related
    ENSMUSP00000147579.1, ENSMUST00000211136.1
    Conserved Domains (3) summary
    pfam01857
    Location:788968
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:371563
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:101210
    DUF3452; Domain of unknown function (DUF3452)
  2. NM_001282001.1NP_001268930.1  retinoblastoma-like protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AI323872, AK160027, BY270001, CF736271
    Consensus CDS
    CCDS85580.1
    UniProtKB/Swiss-Prot
    Q64700
    UniProtKB/TrEMBL
    A0A1B0GR06
    Related
    ENSMUSP00000147327.1, ENSMUST00000209518.1
    Conserved Domains (3) summary
    pfam01857
    Location:8211001
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:414596
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:101233
    DUF3452; Domain of unknown function (DUF3452)
  3. NM_011250.4NP_035380.3  retinoblastoma-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_035380.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI323872, AK160027, BY270001, CF736271
    Consensus CDS
    CCDS22518.1
    UniProtKB/Swiss-Prot
    Q64700
    Related
    ENSMUSP00000034091.7, ENSMUST00000034091.7
    Conserved Domains (3) summary
    pfam01857
    Location:8311011
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:414606
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:101233
    DUF3452; Domain of unknown function (DUF3452)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p6 C57BL/6J

    Range
    91070057..91123844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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