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Rbl2 RB transcriptional corepressor like 2 [ Mus musculus (house mouse) ]

Gene ID: 19651, updated on 23-Jun-2021

Summary

Official Symbol
Rbl2provided by MGI
Official Full Name
RB transcriptional corepressor like 2provided by MGI
Primary source
MGI:MGI:105085
See related
Ensembl:ENSMUSG00000031666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rb; Rb2; p13; PRB2; p130; RBR-2
Expression
Ubiquitous expression in testis adult (RPKM 14.0), bladder adult (RPKM 10.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rbl2 in Genome Data Viewer
Location:
8 C4; 8 44.25 cM
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (91796685..91850472)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (91070057..91123844)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (93593993..93647743)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1483 Neighboring gene chromodomain helicase DNA binding protein 9 Neighboring gene predicted gene, 39221 Neighboring gene predicted gene, 22428 Neighboring gene AKT interacting protein Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene predicted gene, 36243 Neighboring gene Rpgrip1-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of lipid kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
retinoblastoma-like protein 2
Names
130 kDa retinoblastoma-associated protein
retinoblastoma-like 2
retinoblastoma-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282000.1NP_001268929.1  retinoblastoma-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI323872, AK160027, BY270001, CF736271
    Consensus CDS
    CCDS85581.1
    UniProtKB/Swiss-Prot
    Q64700
    UniProtKB/TrEMBL
    A0A1B0GRM0
    Related
    ENSMUSP00000147579.2, ENSMUST00000211136.2
    Conserved Domains (3) summary
    pfam01857
    Location:788968
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:371563
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:101210
    DUF3452; Domain of unknown function (DUF3452)
  2. NM_001282001.1NP_001268930.1  retinoblastoma-like protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AI323872, AK160027, BY270001, CF736271
    Consensus CDS
    CCDS85580.1
    UniProtKB/Swiss-Prot
    Q64700
    UniProtKB/TrEMBL
    A0A1B0GR06
    Related
    ENSMUSP00000147327.2, ENSMUST00000209518.2
    Conserved Domains (3) summary
    pfam01857
    Location:8211001
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:414596
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:101233
    DUF3452; Domain of unknown function (DUF3452)
  3. NM_011250.4NP_035380.3  retinoblastoma-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_035380.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI323872, AK160027, BY270001, CF736271
    Consensus CDS
    CCDS22518.1
    UniProtKB/Swiss-Prot
    Q64700
    Related
    ENSMUSP00000034091.8, ENSMUST00000034091.8
    Conserved Domains (3) summary
    pfam01857
    Location:8311011
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:414606
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:101233
    DUF3452; Domain of unknown function (DUF3452)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    91796685..91850472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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