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PIANP PILR alpha associated neural protein [ Homo sapiens (human) ]

Gene ID: 196500, updated on 23-Nov-2021

Summary

Official Symbol
PIANPprovided by HGNC
Official Full Name
PILR alpha associated neural proteinprovided by HGNC
Primary source
HGNC:HGNC:25338
See related
Ensembl:ENSG00000139200 MIM:616065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PANP; LEDA1; leda-1; C12orf53
Summary
This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Sep 2011]
Expression
Biased expression in brain (RPKM 10.4), endometrium (RPKM 2.8) and 3 other tissues See more
Orthologs
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Genomic context

See PIANP in Genome Data Viewer
Location:
12p13.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6689705..6700815, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6802957..6809981, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene inhibitor of growth family member 4 Neighboring gene zinc finger protein 384 Neighboring gene RNA, U6 small nuclear 781, pseudogene Neighboring gene COP9 signalosome subunit 7A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547D2210

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
PILR alpha-associated neural protein
Names
PILR-associating neural protein
liver endothelial differentiation-associated protein-1
paired immunoglobin-like type 2 receptor-associating neural protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029972.2 RefSeqGene

    Range
    5029..12053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001244014.2NP_001230943.1  PILR alpha-associated neural protein isoform b precursor

    See identical proteins and their annotated locations for NP_001230943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate segment in the 3' coding region and UTR, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AY358534, DA090039
    Consensus CDS
    CCDS58205.1
    UniProtKB/Swiss-Prot
    Q8IYJ0
    Related
    ENSP00000443919.1, ENST00000534837.6
    Conserved Domains (1) summary
    pfam15298
    Location:195236
    AJAP1_PANP_C; AJAP1/PANP C-terminus
  2. NM_001244015.2NP_001230944.1  PILR alpha-associated neural protein isoform a precursor

    See identical proteins and their annotated locations for NP_001230944.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode isoform a.
    Source sequence(s)
    AA653479, AK095854, BM703122
    Consensus CDS
    CCDS44818.1
    UniProtKB/Swiss-Prot
    Q8IYJ0
    Related
    ENSP00000442157.1, ENST00000540656.5
    Conserved Domains (1) summary
    pfam15298
    Location:195236
    AJAP1_PANP_C; AJAP1/PANP C-terminus
  3. NM_153685.4NP_710152.1  PILR alpha-associated neural protein isoform a precursor

    See identical proteins and their annotated locations for NP_710152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC035736, DA090039
    Consensus CDS
    CCDS44818.1
    UniProtKB/Swiss-Prot
    Q8IYJ0
    Related
    ENSP00000317818.5, ENST00000320591.9
    Conserved Domains (1) summary
    pfam15298
    Location:195236
    AJAP1_PANP_C; AJAP1/PANP C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6689705..6700815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520926.3XP_011519228.1  PILR alpha-associated neural protein isoform X1

    See identical proteins and their annotated locations for XP_011519228.1

    Conserved Domains (1) summary
    pfam15298
    Location:195236
    AJAP1_PANP_C; AJAP1/PANP C-terminus
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