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PLBD2 phospholipase B domain containing 2 [ Homo sapiens (human) ]

Gene ID: 196463, updated on 13-Mar-2020

Summary

Official Symbol
PLBD2provided by HGNC
Official Full Name
phospholipase B domain containing 2provided by HGNC
Primary source
HGNC:HGNC:27283
See related
Ensembl:ENSG00000151176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P76
Expression
Ubiquitous expression in adrenal (RPKM 36.9), ovary (RPKM 20.4) and 25 other tissues See more
Orthologs

Genomic context

See PLBD2 in Genome Data Viewer
Location:
12q24.13
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (113358576..113391629)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113796371..113827458)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene two pore segment channel 1 Neighboring gene uncharacterized LOC107984436 Neighboring gene solute carrier family 8 member B1 Neighboring gene uncharacterized LOC105369989 Neighboring gene serine dehydratase Neighboring gene serine dehydratase like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phospholipase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
lysosomal lumen IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative phospholipase B-like 2
Names
76 kDa protein
LAMA-like protein 2
PLB homolog 2
lamina ancestor homolog 2
mannose-6-phosphate protein associated protein p76
phospholipase B domain-containing protein 2
phospholipase B-like 2 32 kDa form
phospholipase B-like 2 45 kDa form
NP_001153199.1
NP_775813.2
XP_011536325.1
XP_016874466.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159727.2NP_001153199.1  putative phospholipase B-like 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC010178
    Consensus CDS
    CCDS53834.1
    UniProtKB/Swiss-Prot
    Q8NHP8
    Related
    ENSP00000443463.2, ENST00000545182.6
    Conserved Domains (1) summary
    pfam04916
    Location:81552
    Phospholip_B; Phospholipase B
  2. NM_173542.4NP_775813.2  putative phospholipase B-like 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_775813.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010178, BC030618, CN412955
    Consensus CDS
    CCDS9168.1
    UniProtKB/Swiss-Prot
    Q8NHP8
    Related
    ENSP00000280800.3, ENST00000280800.5
    Conserved Domains (1) summary
    pfam04916
    Location:81584
    Phospholip_B; Phospholipase B

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    113358576..113391629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018977.1XP_016874466.1  putative phospholipase B-like 2 isoform X2

  2. XM_011538023.2XP_011536325.1  putative phospholipase B-like 2 isoform X1

    Conserved Domains (1) summary
    pfam04916
    Location:2459
    Phospholip_B; Phospholipase B
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