U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZFC3H1 zinc finger C3H1-type containing [ Homo sapiens (human) ]

Gene ID: 196441, updated on 9-Feb-2025

Summary

Official Symbol
ZFC3H1provided by HGNC
Official Full Name
zinc finger C3H1-type containingprovided by HGNC
Primary source
HGNC:HGNC:28328
See related
Ensembl:ENSG00000133858 MIM:620956; AllianceGenome:HGNC:28328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSRC2; PSRC2; CCDC131
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in RNA processing. Located in nucleus. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Feb 2025]
Expression
Ubiquitous expression in lymph node (RPKM 12.9), testis (RPKM 11.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZFC3H1 in Genome Data Viewer
Location:
12q21.1
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (71609599..71663848, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (71587106..71641357, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (72003379..72057628, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing G protein-coupled receptor 5 Neighboring gene uncharacterized LOC124902963 Neighboring gene uncharacterized LOC124902964 Neighboring gene MPRA-validated peak1819 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:71985323-71985838 Neighboring gene MPRA-validated peak1820 silencer Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6659 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:72057723-72058281 Neighboring gene uncharacterized LOC124902965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4658 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:72080194-72080409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6661 Neighboring gene THAP domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6662 Neighboring gene transmembrane protein 19

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0546, MGC23401, MGC90200, DKFZp686A0722

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space HDA PubMed 
part_of nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger C3H1 domain-containing protein
Names
coiled-coil domain containing 131
coiled-coil domain-containing protein 131
proline/serine-rich coiled-coil 2
proline/serine-rich coiled-coil protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144982.5NP_659419.3  zinc finger C3H1 domain-containing protein

    See identical proteins and their annotated locations for NP_659419.3

    Status: VALIDATED

    Source sequence(s)
    AB011118, AC073612, BX647709
    Consensus CDS
    CCDS41813.1
    UniProtKB/Swiss-Prot
    O60293, Q6GMU1, Q6P2S9, Q6ZV36, Q96BE7
    Related
    ENSP00000368017.4, ENST00000378743.9
    Conserved Domains (5) summary
    COG0457
    Location:13831667
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:16041630
    TPR; TPR repeat [structural motif]
    pfam10650
    Location:11861204
    zf-C3H1; Putative zinc-finger domain
    pfam13414
    Location:13621432
    TPR_11; TPR repeat
    pfam13428
    Location:13611410
    TPR_14; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    71609599..71663848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428485.1XP_047284441.1  zinc finger C3H1 domain-containing protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    71587106..71641357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)