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METTL7B methyltransferase like 7B [ Homo sapiens (human) ]

Gene ID: 196410, updated on 5-Aug-2022

Summary

Official Symbol
METTL7Bprovided by HGNC
Official Full Name
methyltransferase like 7Bprovided by HGNC
Primary source
HGNC:HGNC:28276
See related
Ensembl:ENSG00000170439 AllianceGenome:HGNC:28276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALDI
Summary
Enables thiol S-methyltransferase activity. Predicted to be involved in methylation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver (RPKM 58.0), duodenum (RPKM 25.7) and 7 other tissues See more
Orthologs
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Genomic context

See METTL7B in Genome Data Viewer
Location:
12q13.2
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (55681736..55684611)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (55648368..55651240)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56075520..56078395)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs2573 Neighboring gene proteasome subunit beta 3 pseudogene 1 Neighboring gene integrin subunit alpha 7 Neighboring gene BLOC1S1-RDH5 readthrough Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 1 Neighboring gene retinol dehydrogenase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17301

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiol S-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thiol S-methyltransferase METTL7B
Names
associated with lipid droplets 1
methyltransferase-like protein 7B
NP_689850.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152637.3NP_689850.2  thiol S-methyltransferase METTL7B precursor

    See identical proteins and their annotated locations for NP_689850.2

    Status: VALIDATED

    Source sequence(s)
    AK290112, BC020509
    Consensus CDS
    CCDS8887.2
    UniProtKB/Swiss-Prot
    Q6UX53, Q8WUI1
    Related
    ENSP00000377796.3, ENST00000394252.4
    Conserved Domains (1) summary
    pfam08241
    Location:75172
    Methyltransf_11; Methyltransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    55681736..55684611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    55648368..55651240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)