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DTX3 deltex E3 ubiquitin ligase 3 [ Homo sapiens (human) ]

Gene ID: 196403, updated on 13-Mar-2020

Summary

Official Symbol
DTX3provided by HGNC
Official Full Name
deltex E3 ubiquitin ligase 3provided by HGNC
Primary source
HGNC:HGNC:24457
See related
Ensembl:ENSG00000178498 MIM:613142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF154; deltex3
Summary
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Expression
Ubiquitous expression in brain (RPKM 21.6), endometrium (RPKM 16.7) and 24 other tissues See more
Orthologs

Genomic context

See DTX3 in Genome Data Viewer
Location:
12q13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (57604327..57609802)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57998110..58003585)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene kinesin family member 5A Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma Neighboring gene Rho guanine nucleotide exchange factor 25 Neighboring gene uncharacterized LOC101927583 Neighboring gene solute carrier family 26 member 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34766, MGC138863, MGC138864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase DTX3
Names
RING finger protein 154
RING-type E3 ubiquitin transferase DTX3
deltex 3, E3 ubiquitin ligase
deltex homolog 3
protein deltex-3
NP_001273174.1
NP_001273175.1
NP_848597.1
XP_005268754.1
XP_005268755.1
XP_005268757.1
XP_005268760.1
XP_011536324.1
XP_024304644.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286245.2NP_001273174.1  probable E3 ubiquitin-protein ligase DTX3 isoform b

    See identical proteins and their annotated locations for NP_001273174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, uses an alternate splice site in the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AK094385, DA684401
    Consensus CDS
    CCDS66410.1
    UniProtKB/Swiss-Prot
    Q8N9I9
    Related
    ENSP00000448696.1, ENST00000551632.1
    Conserved Domains (2) summary
    cd09633
    Location:214346
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16711
    Location:166206
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
  2. NM_001286246.2NP_001273175.1  probable E3 ubiquitin-protein ligase DTX3 isoform a

    See identical proteins and their annotated locations for NP_001273175.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK094385, DA684401
    Consensus CDS
    CCDS41800.1
    UniProtKB/Swiss-Prot
    Q8N9I9
    UniProtKB/TrEMBL
    A0A024RB96
    Related
    ENSP00000449294.1, ENST00000548804.5
    Conserved Domains (2) summary
    cd09633
    Location:211343
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16711
    Location:163203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
  3. NM_178502.4NP_848597.1  probable E3 ubiquitin-protein ligase DTX3 isoform a

    See identical proteins and their annotated locations for NP_848597.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK092085, AK094385
    Consensus CDS
    CCDS41800.1
    UniProtKB/Swiss-Prot
    Q8N9I9
    UniProtKB/TrEMBL
    A0A024RB96
    Related
    ENSP00000338050.3, ENST00000337737.8
    Conserved Domains (2) summary
    cd09633
    Location:211343
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16711
    Location:163203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    57604327..57609802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448876.1XP_024304644.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

    Conserved Domains (2) summary
    cd09633
    Location:211343
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16711
    Location:163203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
  2. XM_005268697.1XP_005268754.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

    See identical proteins and their annotated locations for XP_005268754.1

    UniProtKB/Swiss-Prot
    Q8N9I9
    Conserved Domains (2) summary
    cd09633
    Location:214346
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16711
    Location:166206
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
  3. XM_005268698.1XP_005268755.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

    See identical proteins and their annotated locations for XP_005268755.1

    UniProtKB/Swiss-Prot
    Q8N9I9
    Conserved Domains (2) summary
    cd09633
    Location:214346
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16711
    Location:166206
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
  4. XM_005268703.1XP_005268760.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

    See identical proteins and their annotated locations for XP_005268760.1

    UniProtKB/Swiss-Prot
    Q8N9I9
    UniProtKB/TrEMBL
    A0A024RB96
    Conserved Domains (2) summary
    cd09633
    Location:211343
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16711
    Location:163203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
  5. XM_005268700.1XP_005268757.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

    See identical proteins and their annotated locations for XP_005268757.1

    UniProtKB/Swiss-Prot
    Q8N9I9
    Conserved Domains (2) summary
    cd09633
    Location:214346
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16711
    Location:166206
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
  6. XM_011538022.2XP_011536324.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

    See identical proteins and their annotated locations for XP_011536324.1

    UniProtKB/Swiss-Prot
    Q8N9I9
    UniProtKB/TrEMBL
    A0A024RB96
    Related
    ENSP00000447873.1, ENST00000548198.5
    Conserved Domains (2) summary
    cd09633
    Location:211343
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16711
    Location:163203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
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