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IMMP1L inner mitochondrial membrane peptidase subunit 1 [ Homo sapiens (human) ]

Gene ID: 196294, updated on 13-Mar-2020

Summary

Official Symbol
IMMP1Lprovided by HGNC
Official Full Name
inner mitochondrial membrane peptidase subunit 1provided by HGNC
Primary source
HGNC:HGNC:26317
See related
Ensembl:ENSG00000148950 MIM:612323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMP1; IMMP1; IMP1-LIKE
Summary
The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).[supplied by OMIM, Sep 2008]
Expression
Ubiquitous expression in fat (RPKM 7.2), prostate (RPKM 6.9) and 25 other tissues See more
Orthologs

Genomic context

See IMMP1L in Genome Data Viewer
Location:
11p13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (31432401..31509644, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (31453948..31531169, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376611 Neighboring gene doublecortin domain containing 1 Neighboring gene CYCS pseudogene 25 Neighboring gene DnaJ heat shock protein family (Hsp40) member C24 Neighboring gene HCNE8 enhancer downstream of PAX6 Neighboring gene RB enhancer downstream of PAX6 Neighboring gene elongator acetyltransferase complex subunit 4 Neighboring gene PAX6 downstream regulatory region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25059

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
protein processing involved in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
mitochondrial inner membrane protease subunit 1
Names
IMP1 inner mitochondrial membrane peptidase-like
NP_001291203.1
NP_659418.1
XP_005252869.1
XP_011518244.1
XP_011518245.1
XP_011518246.1
XP_011518247.1
XP_011518248.1
XP_011518249.1
XP_016872794.1
XP_016872795.1
XP_016872796.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304274.2NP_001291203.1  mitochondrial inner membrane protease subunit 1

    See identical proteins and their annotated locations for NP_001291203.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC023595, DB288287
    Consensus CDS
    CCDS7874.1
    UniProtKB/Swiss-Prot
    Q96LU5
    Related
    ENSP00000435576.1, ENST00000532287.6
    Conserved Domains (1) summary
    TIGR02227
    Location:29149
    sigpep_I_bact; signal peptidase I, bacterial type
  2. NM_144981.3NP_659418.1  mitochondrial inner membrane protease subunit 1

    See identical proteins and their annotated locations for NP_659418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK057788, AW295209, DB288287
    Consensus CDS
    CCDS7874.1
    UniProtKB/Swiss-Prot
    Q96LU5
    Related
    ENSP00000278200.1, ENST00000278200.5
    Conserved Domains (1) summary
    TIGR02227
    Location:29149
    sigpep_I_bact; signal peptidase I, bacterial type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    31432401..31509644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017306.1XP_016872795.1  mitochondrial inner membrane protease subunit 1 isoform X2

  2. XM_011519947.2XP_011518249.1  mitochondrial inner membrane protease subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_011518249.1

    UniProtKB/Swiss-Prot
    Q96LU5
    Conserved Domains (1) summary
    TIGR02227
    Location:29149
    sigpep_I_bact; signal peptidase I, bacterial type
  3. XM_011519945.2XP_011518247.1  mitochondrial inner membrane protease subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_011518247.1

    UniProtKB/Swiss-Prot
    Q96LU5
    Conserved Domains (1) summary
    TIGR02227
    Location:29149
    sigpep_I_bact; signal peptidase I, bacterial type
  4. XM_011519946.2XP_011518248.1  mitochondrial inner membrane protease subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_011518248.1

    UniProtKB/Swiss-Prot
    Q96LU5
    Conserved Domains (1) summary
    TIGR02227
    Location:29149
    sigpep_I_bact; signal peptidase I, bacterial type
  5. XM_011519944.2XP_011518246.1  mitochondrial inner membrane protease subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_011518246.1

    UniProtKB/Swiss-Prot
    Q96LU5
    Conserved Domains (1) summary
    TIGR02227
    Location:29149
    sigpep_I_bact; signal peptidase I, bacterial type
  6. XM_017017305.1XP_016872794.1  mitochondrial inner membrane protease subunit 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96LU5
    Conserved Domains (1) summary
    TIGR02227
    Location:29149
    sigpep_I_bact; signal peptidase I, bacterial type
  7. XM_005252812.3XP_005252869.1  mitochondrial inner membrane protease subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_005252869.1

    UniProtKB/Swiss-Prot
    Q96LU5
    Conserved Domains (1) summary
    TIGR02227
    Location:29149
    sigpep_I_bact; signal peptidase I, bacterial type
  8. XM_011519943.2XP_011518245.1  mitochondrial inner membrane protease subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_011518245.1

    UniProtKB/Swiss-Prot
    Q96LU5
    Conserved Domains (1) summary
    TIGR02227
    Location:29149
    sigpep_I_bact; signal peptidase I, bacterial type
  9. XM_011519942.1XP_011518244.1  mitochondrial inner membrane protease subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_011518244.1

    UniProtKB/Swiss-Prot
    Q96LU5
    Conserved Domains (1) summary
    TIGR02227
    Location:29149
    sigpep_I_bact; signal peptidase I, bacterial type
  10. XM_017017307.1XP_016872796.1  mitochondrial inner membrane protease subunit 1 isoform X3

    Related
    ENSP00000432001.1, ENST00000529749.5

RNA

  1. XR_242781.3 RNA Sequence

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