Format

Send to:

Choose Destination

MPZL3 myelin protein zero like 3 [ Homo sapiens (human) ]

Gene ID: 196264, updated on 11-Sep-2019

Summary

Official Symbol
MPZL3provided by HGNC
Official Full Name
myelin protein zero like 3provided by HGNC
Primary source
HGNC:HGNC:27279
See related
Ensembl:ENSG00000160588 MIM:611707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in skin (RPKM 9.4), esophagus (RPKM 9.0) and 19 other tissues See more
Orthologs

Genomic context

See MPZL3 in Genome Data Viewer
Location:
11q23.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (118226690..118252365, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118097405..118124135, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel beta subunit 2 Neighboring gene junction adhesion molecule like Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 18 Neighboring gene myelin protein zero like 2 Neighboring gene Sharpr-MPRA regulatory region 14251

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
hair cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myelin protein zero-like protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286152.2NP_001273081.1  myelin protein zero-like protein 3 isoform b precursor

    See identical proteins and their annotated locations for NP_001273081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AP002800, BC113586, BC143897, DC417020
    Consensus CDS
    CCDS66241.1
    UniProtKB/Swiss-Prot
    Q6UWV2
    Related
    ENSP00000432106.1, ENST00000527472.1
    Conserved Domains (2) summary
    smart00410
    Location:27135
    IG_like; Immunoglobulin like
    cl11960
    Location:23125
    Ig; Immunoglobulin domain
  2. NM_198275.3NP_938016.1  myelin protein zero-like protein 3 isoform a precursor

    See identical proteins and their annotated locations for NP_938016.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AP002800, BC113586, DC417020
    Consensus CDS
    CCDS8392.1
    UniProtKB/Swiss-Prot
    Q6UWV2
    Related
    ENSP00000278949.4, ENST00000278949.9
    Conserved Domains (2) summary
    smart00410
    Location:39147
    IG_like; Immunoglobulin like
    cl11960
    Location:33137
    Ig; Immunoglobulin domain

RNA

  1. NR_104404.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AK310966, AP002800, DC417020
  2. NR_104405.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK296951, AK304292, AP002800, DC417020

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    118226690..118252365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718775.2XP_006718838.1  myelin protein zero-like protein 3 isoform X2

    Conserved Domains (2) summary
    smart00410
    Location:21129
    IG_like; Immunoglobulin like
    cl11960
    Location:15119
    Ig; Immunoglobulin domain
  2. XM_017017304.1XP_016872793.1  myelin protein zero-like protein 3 isoform X1

Support Center