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PLPP4 phospholipid phosphatase 4 [ Homo sapiens (human) ]

Gene ID: 196051, updated on 23-Nov-2021

Summary

Official Symbol
PLPP4provided by HGNC
Official Full Name
phospholipid phosphatase 4provided by HGNC
Primary source
HGNC:HGNC:23531
See related
Ensembl:ENSG00000203805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPPL2; PPAPDC1; PPAPDC1A
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See PLPP4 in Genome Data Viewer
Location:
10q26.12
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (120456954..120600123)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (122216466..122351577)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378515 Neighboring gene ribosomal protein L21 pseudogene 16 Neighboring gene long intergenic non-protein coding RNA 1561 Neighboring gene long intergenic non-protein coding RNA 2930 Neighboring gene WDR11 divergent transcript Neighboring gene uncharacterized LOC105378519 Neighboring gene WD repeat domain 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC120299, MGC120300

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables diacylglycerol diphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidate phosphatase activity EXP
Inferred from Experiment
more info
PubMed 
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
involved_in blastocyst hatching IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of calcium ion import IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
phospholipid phosphatase 4
Names
diacylglycerol pyrophosphate like 2
diacylglycerol pyrophosphate phosphatase-like 2
phosphatidate phosphatase PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
phosphatidic acid phosphatase type 2 domain-containing protein 1A
NP_001025230.1
NP_001305095.1
NP_001305096.1
NP_001305097.1
NP_001305098.1
XP_005269649.1
XP_006717748.1
XP_006717749.1
XP_011537746.1
XP_011537747.1
XP_016871309.1
XP_016871310.1
XP_016871311.1
XP_016871312.1
XP_016871313.1
XP_024303628.1
XP_024303629.1
XP_024303630.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030059.3NP_001025230.1  phospholipid phosphatase 4 isoform a

    See identical proteins and their annotated locations for NP_001025230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC023282, BC132787, DR000933, HY340365
    Consensus CDS
    CCDS41573.1
    UniProtKB/Swiss-Prot
    Q5VZY2
    Related
    ENSP00000381302.1, ENST00000398250.6
    Conserved Domains (1) summary
    cd03390
    Location:37225
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
  2. NM_001318166.2NP_001305095.1  phospholipid phosphatase 4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC023282, BC101267, DB473853, DR000933, HY340365
    UniProtKB/Swiss-Prot
    Q5VZY2
    Conserved Domains (1) summary
    cl00474
    Location:37106
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
  3. NM_001318167.2NP_001305096.1  phospholipid phosphatase 4 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons, resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC023282, BC101268, DR000933, HY340365
    UniProtKB/Swiss-Prot
    Q5VZY2
    Conserved Domains (1) summary
    cl00474
    Location:37162
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
  4. NM_001318168.2NP_001305097.1  phospholipid phosphatase 4 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate exons, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC023282, BC101267, DR000933, HY340365
    UniProtKB/Swiss-Prot
    Q5VZY2
  5. NM_001318169.2NP_001305098.1  phospholipid phosphatase 4 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks four alternate exons, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC023282, BC122535, DR000933, HY340365
    UniProtKB/Swiss-Prot
    Q5VZY2

RNA

  1. NR_134516.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) splices out a 5' region and lacks three internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC073587, BC101269, BI459587, DB495310, HY340365

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    120456954..120600123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269592.2XP_005269649.1  phospholipid phosphatase 4 isoform X6

    Conserved Domains (1) summary
    cd03390
    Location:37168
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
  2. XM_011539445.2XP_011537747.1  phospholipid phosphatase 4 isoform X3

    See identical proteins and their annotated locations for XP_011537747.1

    UniProtKB/TrEMBL
    B7Z3R3
    Conserved Domains (1) summary
    cd03390
    Location:37205
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
  3. XM_006717686.4XP_006717749.1  phospholipid phosphatase 4 isoform X4

    Conserved Domains (1) summary
    cd03390
    Location:37207
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
  4. XM_017015824.2XP_016871313.1  phospholipid phosphatase 4 isoform X8

  5. XM_017015823.1XP_016871312.1  phospholipid phosphatase 4 isoform X8

  6. XM_024447861.1XP_024303629.1  phospholipid phosphatase 4 isoform X7

    Conserved Domains (1) summary
    cd03390
    Location:7104
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
  7. XM_024447860.1XP_024303628.1  phospholipid phosphatase 4 isoform X7

    Conserved Domains (1) summary
    cd03390
    Location:7104
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
  8. XM_006717685.4XP_006717748.1  phospholipid phosphatase 4 isoform X2

    Conserved Domains (1) summary
    cd03390
    Location:24212
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
  9. XM_011539444.3XP_011537746.1  phospholipid phosphatase 4 isoform X1

    Conserved Domains (1) summary
    cd03390
    Location:35223
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
  10. XM_017015820.1XP_016871309.1  phospholipid phosphatase 4 isoform X5

  11. XM_024447862.1XP_024303630.1  phospholipid phosphatase 4 isoform X7

    Conserved Domains (1) summary
    cd03390
    Location:7104
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
  12. XM_017015822.1XP_016871311.1  phospholipid phosphatase 4 isoform X7

    Conserved Domains (1) summary
    cd03390
    Location:7104
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
  13. XM_017015821.2XP_016871310.1  phospholipid phosphatase 4 isoform X7

    Conserved Domains (1) summary
    cd03390
    Location:7104
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...
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