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PRXL2C peroxiredoxin like 2C [ Homo sapiens (human) ]

Gene ID: 195827, updated on 1-Jun-2020

Summary

Official Symbol
PRXL2Cprovided by HGNC
Official Full Name
peroxiredoxin like 2Cprovided by HGNC
Primary source
HGNC:HGNC:16881
See related
Ensembl:ENSG00000158122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAED1; C9orf21
Expression
Ubiquitous expression in thyroid (RPKM 7.8), gall bladder (RPKM 7.6) and 25 other tissues See more
Orthologs

Genomic context

See PRXL2C in Genome Data Viewer
Location:
9q22.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (96639577..96655331, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (99403109..99417603, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene hyaluronan binding protein 4 Neighboring gene cell division cycle 14B Neighboring gene uncharacterized LOC105376163 Neighboring gene makorin ring finger protein 1 pseudogene Neighboring gene zinc finger protein 510

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antioxidant activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
peroxiredoxin-like 2C
Names
AhpC/TSA antioxidant enzyme domain containing 1
UPF0308 protein C9orf21
ahpC/TSA antioxidant enzyme domain-containing protein 1
thioredoxin-like protein AAED1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153698.2NP_714542.1  peroxiredoxin-like 2C

    See identical proteins and their annotated locations for NP_714542.1

    Status: VALIDATED

    Source sequence(s)
    AL353578, BF445089, BM843088, BU631382
    Consensus CDS
    CCDS35073.1
    UniProtKB/Swiss-Prot
    Q7RTV5
    Related
    ENSP00000364382.3, ENST00000375234.8
    Conserved Domains (1) summary
    cd02970
    Location:34195
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    96639577..96655331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251784.4XP_005251841.1  peroxiredoxin-like 2C isoform X2

    See identical proteins and their annotated locations for XP_005251841.1

    UniProtKB/TrEMBL
    B7ZKK1
    Related
    ENSP00000398933.1, ENST00000446045.1
    Conserved Domains (1) summary
    cd02970
    Location:11141
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
  2. XM_005251783.3XP_005251840.1  peroxiredoxin-like 2C isoform X1

    See identical proteins and their annotated locations for XP_005251840.1

    Conserved Domains (1) summary
    cd02970
    Location:34168
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
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