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Gsc2 goosecoid homebox 2 [ Mus musculus (house mouse) ]

Gene ID: 195333, updated on 26-Sep-2022

Summary

Official Symbol
Gsc2provided by MGI
Official Full Name
goosecoid homebox 2provided by MGI
Primary source
MGI:MGI:892006
See related
Ensembl:ENSMUSG00000022738 AllianceGenome:MGI:892006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gscl; GSC-2; 4930568H22Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; and retina. Orthologous to human GSC2 (goosecoid homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 1.7), testis adult (RPKM 1.2) and 4 other tissues See more
Orthologs
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Genomic context

See Gsc2 in Genome Data Viewer
Location:
16 A3; 16 11.1 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17730978..17732891, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17913114..17915027, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene testis-specific serine kinase 2 Neighboring gene ess-2 splicing factor Neighboring gene solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 Neighboring gene predicted gene, 41427

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein goosecoid-2
Names
GSC-L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029469.2NP_083745.2  homeobox protein goosecoid-2

    Status: VALIDATED

    Source sequence(s)
    AK016252, BC125356
    Consensus CDS
    CCDS49786.2
    UniProtKB/Swiss-Prot
    Q05A98
    Related
    ENSMUSP00000012279.5, ENSMUST00000012279.6
    Conserved Domains (1) summary
    pfam00046
    Location:126180
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17730978..17732891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)