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MEGF6 multiple EGF like domains 6 [ Homo sapiens (human) ]

Gene ID: 1953, updated on 1-Jun-2020

Summary

Official Symbol
MEGF6provided by HGNC
Official Full Name
multiple EGF like domains 6provided by HGNC
Primary source
HGNC:HGNC:3232
See related
Ensembl:ENSG00000162591 MIM:604266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGFL3
Expression
Broad expression in skin (RPKM 15.1), lung (RPKM 6.0) and 20 other tissues See more
Orthologs

Genomic context

See MEGF6 in Genome Data Viewer
Location:
1p36.32
Exon count:
41
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (3487951..3624770, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3404506..3528059, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PR/SET domain 16 Neighboring gene VISTA enhancer hs1912 Neighboring gene Rho guanine nucleotide exchange factor 16 Neighboring gene MEGF6 intron CAGE-defined mid-level expression enhancer Neighboring gene uncharacterized LOC105378608 Neighboring gene microRNA 551a Neighboring gene uncharacterized LOC105378607 Neighboring gene tumor protein p63 regulated 1 like Neighboring gene WD repeat containing, antisense to TP73

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0815

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
multiple epidermal growth factor-like domains protein 6
Names
EGF-like protein 3
EGF-like-domain, multiple 3
epidermal growth factor-like protein 3
multiple EGF-like domains protein 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409.4NP_001400.3  multiple epidermal growth factor-like domains protein 6 precursor

    See identical proteins and their annotated locations for NP_001400.3

    Status: VALIDATED

    Source sequence(s)
    AB011539, AB231860, AL512413, AL513320, BM984873, BU501408
    Consensus CDS
    CCDS41237.1
    UniProtKB/Swiss-Prot
    O75095
    Related
    ENSP00000348982.4, ENST00000356575.9
    Conserved Domains (3) summary
    pfam07546
    Location:46114
    EMI; EMI domain
    pfam14670
    Location:335370
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:153199
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    3487951..3624770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000533.2XP_016856022.1  multiple epidermal growth factor-like domains protein 6 isoform X3

  2. XM_011540886.2XP_011539188.1  multiple epidermal growth factor-like domains protein 6 isoform X2

    Conserved Domains (3) summary
    pfam07546
    Location:108176
    EMI; EMI domain
    pfam14670
    Location:397432
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:215261
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  3. XM_011540885.2XP_011539187.1  multiple epidermal growth factor-like domains protein 6 isoform X1

    Conserved Domains (3) summary
    pfam07546
    Location:108176
    EMI; EMI domain
    pfam14670
    Location:397432
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:215261
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  4. XM_011540887.2XP_011539189.1  multiple epidermal growth factor-like domains protein 6 isoform X5

    Conserved Domains (2) summary
    pfam14670
    Location:189224
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:134176
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  5. XM_006710406.4XP_006710469.1  multiple epidermal growth factor-like domains protein 6 isoform X4

    Related
    ENSP00000294599.4, ENST00000294599.8
    Conserved Domains (2) summary
    pfam14670
    Location:230265
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:175217
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  6. XM_011540888.3XP_011539190.1  multiple epidermal growth factor-like domains protein 6 isoform X6

    Conserved Domains (3) summary
    pfam07546
    Location:108176
    EMI; EMI domain
    pfam14670
    Location:397432
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:215261
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
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