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CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 [ Homo sapiens (human) ]

Gene ID: 1951, updated on 18-Sep-2018

Summary

Official Symbol
CELSR3provided by HGNC
Official Full Name
cadherin EGF LAG seven-pass G-type receptor 3provided by HGNC
Primary source
HGNC:HGNC:3230
See related
Ensembl:ENSG00000008300 MIM:604264; Vega:OTTHUMG00000133544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FMI1; EGFL1; HFMI1; MEGF2; ADGRC3; CDHF11; RESDA1
Summary
This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
Expression
Broad expression in brain (RPKM 3.0), testis (RPKM 2.3) and 17 other tissues See more
Orthologs

Genomic context

See CELSR3 in Genome Data Viewer
Location:
3p21.31
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (48636463..48662915, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48673896..48700348, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 89 Neighboring gene solute carrier family 26 member 6 Neighboring gene microRNA 6824 Neighboring gene microRNA 4793 Neighboring gene long intergenic non-protein coding RNA 2585 Neighboring gene NCK interacting protein with SH3 domain Neighboring gene inositol hexakisphosphate kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
PubMed 
axonal fasciculation IEA
Inferred from Electronic Annotation
more info
 
cilium assembly IEA
Inferred from Electronic Annotation
more info
 
dopaminergic neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
planar cell polarity pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 
regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
serotonergic neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cadherin EGF LAG seven-pass G-type receptor 3
Names
EGF-like protein 1
EGF-like-domain, multiple 1
adhesion G protein-coupled receptor C3
anchor protein
cadherin family member 11
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
epidermal growth factor-like protein 1
flamingo homolog 1
multiple EGF-like domains protein 2
multiple epidermal growth factor-like domains protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034061.1 RefSeqGene

    Range
    5001..31453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001407.2NP_001398.2  cadherin EGF LAG seven-pass G-type receptor 3 precursor

    See identical proteins and their annotated locations for NP_001398.2

    Status: REVIEWED

    Source sequence(s)
    AB011536, AC121252, AF231023, BU738328
    Consensus CDS
    CCDS2775.1
    UniProtKB/Swiss-Prot
    Q9NYQ7
    Related
    ENSP00000164024.4, OTTHUMP00000164826, ENST00000164024.4, OTTHUMT00000257523
    Conserved Domains (9) summary
    smart00303
    Location:24762529
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:655752
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:21262185
    HormR; Domain present in hormone receptors
    cd00054
    Location:19822020
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:20762114
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:15171700
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:20032042
    Laminin_EGF; Laminin EGF domain
    pfam16489
    Location:22052448
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl21561
    Location:25572767
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    48636463..48662915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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