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Tmem199 transmembrane protein 199 [ Mus musculus (house mouse) ]

Gene ID: 195040, updated on 5-Mar-2024

Summary

Official Symbol
Tmem199provided by MGI
Official Full Name
transmembrane protein 199provided by MGI
Primary source
MGI:MGI:2144113
See related
Ensembl:ENSMUSG00000051232 AllianceGenome:MGI:2144113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in cellular cation homeostasis; cellular response to increased oxygen levels; and lysosomal protein catabolic process. Predicted to be located in COPI-coated vesicle membrane; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIp. Orthologous to human TMEM199 (transmembrane protein 199). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 17.9), CNS E18 (RPKM 15.8) and 28 other tissues See more
Orthologs
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Genomic context

See Tmem199 in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78397881..78402994, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78507055..78512168, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene vitronectin Neighboring gene SEBOX homeobox Neighboring gene polymerase (DNA-directed), delta interacting protein 2 Neighboring gene tumor necrosis factor, alpha-induced protein 1 (endothelial)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables oxysterol binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in COPI-coated vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of vacuolar proton-transporting V-type ATPase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transmembrane protein 199
Names
RE40914p

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199199.3NP_954669.2  transmembrane protein 199

    See identical proteins and their annotated locations for NP_954669.2

    Status: VALIDATED

    Source sequence(s)
    BC050977, BY255000
    Consensus CDS
    CCDS25108.1
    UniProtKB/Swiss-Prot
    Q5SYH2
    UniProtKB/TrEMBL
    B2RV69, Q3TZ80
    Related
    ENSMUSP00000058599.8, ENSMUST00000052566.8
    Conserved Domains (2) summary
    pfam11712
    Location:78202
    Vma12; Endoplasmic reticulum-based factor for assembly of V-ATPase
    pfam12240
    Location:974
    Angiomotin_C; Angiomotin C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78397881..78402994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)