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Klf11 Kruppel-like transcription factor 11 [ Mus musculus (house mouse) ]

Gene ID: 194655, updated on 18-Apr-2024

Summary

Official Symbol
Klf11provided by MGI
Official Full Name
Kruppel-like transcription factor 11provided by MGI
Primary source
MGI:MGI:2653368
See related
Ensembl:ENSMUSG00000020653 AllianceGenome:MGI:2653368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tieg2; Tieg3; Tieg2b; 9830142A17; D12Ertd427e
Summary
Enables DNA-binding transcription factor activity. Involved in negative regulation of transcription, DNA-templated. Predicted to be located in cytosol; focal adhesion; and nuclear body. Is expressed in several structures, including brain; early conceptus; genitourinary system; liver; and sensory organ. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 7 and type 2 diabetes mellitus. Orthologous to human KLF11 (Kruppel like factor 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 9.8), ovary adult (RPKM 9.6) and 28 other tissues See more
Orthologs
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Genomic context

Location:
12 A1.3; 12 8.49 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (24701370..24712781)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (24651371..24662782)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:25256927-25257228 Neighboring gene grainyhead like transcription factor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25278331-25278514 Neighboring gene cytochrome c oxidase subunit VIIa polypeptide 2-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E917 Neighboring gene cystin 1 Neighboring gene predicted gene, 36129 Neighboring gene STARR-seq mESC enhancer starr_31755 Neighboring gene predicted gene, 52012

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 11
Names
Kruppel-like factor 11
TGFB inducible early growth response 2
TGFB inducible early growth response 3
TGFB-inducible early growth response protein 2b
TGFB-inducible early growth response protein 3
TIEG-3
transforming growth factor-beta-inducible early growth response protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178357.3NP_848134.1  Krueppel-like factor 11

    See identical proteins and their annotated locations for NP_848134.1

    Status: VALIDATED

    Source sequence(s)
    AK038397, DV654709
    Consensus CDS
    CCDS25842.1
    UniProtKB/Swiss-Prot
    Q8BHJ1, Q8BI37, Q8BI70, Q8K1S5
    Related
    ENSMUSP00000020982.6, ENSMUST00000020982.7
    Conserved Domains (4) summary
    COG5048
    Location:382439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:389408
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:444466
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:430453
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    24701370..24712781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)