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Klf11 Kruppel-like factor 11 [ Mus musculus (house mouse) ]

Gene ID: 194655, updated on 12-Aug-2018

Summary

Official Symbol
Klf11provided by MGI
Official Full Name
Kruppel-like factor 11provided by MGI
Primary source
MGI:MGI:2653368
See related
Ensembl:ENSMUSG00000020653 Vega:OTTMUSG00000027554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tieg2; Tieg3; Tieg2b; 9830142A17; D12Ertd427e
Expression
Ubiquitous expression in lung adult (RPKM 9.8), ovary adult (RPKM 9.6) and 28 other tissues See more
Orthologs

Genomic context

See Klf11 in Genome Data Viewer
Location:
12 A1.3; 12 8.49 cM
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (24651371..24662782)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (25336236..25347647)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene grainyhead like transcription factor 1 Neighboring gene cytochrome c oxidase subunit VIIa polypeptide 2-like pseudogene Neighboring gene cystin 1 Neighboring gene predicted gene, 36129 Neighboring gene ribonucleotide reductase M2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
NOT hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription involved in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 11
Names
TGFB inducible early growth response 2
TGFB inducible early growth response 3
TGFB-inducible early growth response protein 2b
TGFB-inducible early growth response protein 3
TIEG-3
klf11
transforming growth factor-beta-inducible early growth response protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178357.3NP_848134.1  Krueppel-like factor 11

    See identical proteins and their annotated locations for NP_848134.1

    Status: VALIDATED

    Source sequence(s)
    AK038397, DV654709
    Consensus CDS
    CCDS25842.1
    UniProtKB/Swiss-Prot
    Q8K1S5
    Related
    ENSMUSP00000020982.5, OTTMUSP00000034445, ENSMUST00000020982.6, OTTMUST00000068231
    Conserved Domains (4) summary
    COG5048
    Location:382439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:389408
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:444466
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:430453
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    24651371..24662782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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