Tet3 tet methylcytosine dioxygenase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tet3provided by MGI
Official Full Name: tet methylcytosine dioxygenase 3provided by MGI
Primary source: MGI:MGI:2446229
See related: Ensembl:ENSMUSG00000034832 AllianceGenome:MGI:2446229
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B430006D22Rik; D230004J03Rik
Summary: Enables methylcytosine dioxygenase activity. Involved in DNA demethylation of male pronucleus. Acts upstream of or within DNA demethylation. Located in cytoplasm; female pronucleus; and male pronucleus. Is expressed in several structures, including central nervous system; early conceptus; future brain; and genitourinary system. Orthologous to human TET3 (tet methylcytosine dioxygenase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 8.4), thymus adult (RPKM 8.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 C3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83339355..83434190, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83362373..83457208, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation.
Title: DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation.
Deficiency of Tet3 in nucleus accumbens enhances fear generalization and anxiety-like behaviors in mice.
Title: Deficiency of Tet3 in nucleus accumbens enhances fear generalization and anxiety-like behaviors in mice.
TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons.
Title: TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons.
Role of DNA dioxygenase Ten-Eleven translocation 3 (TET3) in rheumatoid arthritis progression.
Title: Role of DNA dioxygenase Ten-Eleven translocation 3 (TET3) in rheumatoid arthritis progression.
Tet3 Deletion in Adult Brain Neurons of Female Mice Results in Anxiety-like Behavior and Cognitive Impairments.
Title: Tet3 Deletion in Adult Brain Neurons of Female Mice Results in Anxiety-like Behavior and Cognitive Impairments.
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation.
Title: Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation.
Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency.
Title: Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency.
DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons.
Title: DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons.
Redirected nuclear glutamate dehydrogenase supplies Tet3 with alpha-ketoglutarate in neurons.
Title: Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons.
TET3 regulates DNA hydroxymethylation of neuroprotective genes following focal ischemia.
Title: TET3 regulates DNA hydroxymethylation of neuroprotective genes following focal ischemia.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6UmiJ15 (e-PCR), detects polymorphism
- UniSTS:260408

D6UmiJ2 (e-PCR), detects polymorphism
- UniSTS:260413

Tet3 (e-PCR), detects polymorphism
- UniSTS:531426

Homology

Homologs of the Tet3 gene: The Tet3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 457 organisms have orthologs with human gene Tet3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables methylcytosine dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables methylcytosine dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables methylcytosine dioxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 5-methylcytosine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in DNA demethylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within DNA demethylation	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA demethylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA demethylation of male pronucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in oxidative demethylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in female pronucleus	IDA Inferred from Direct Assay more info	PubMed
located_in male pronucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: methylcytosine dioxygenase TET3

Names: probable methylcytosine dioxygenase TET3; tet oncogene family member 3

NP_001334242.1

EC 1.14.11.n2

NP_898961.2

EC 1.14.11.n2

XP_006505838.1

EC 1.14.11.n2

XP_006505839.1

EC 1.14.11.n2

XP_006505840.1

EC 1.14.11.n2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347313.1 → NP_001334242.1 methylcytosine dioxygenase TET3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC090648, AC159713

Consensus CDS

CCDS85071.1

UniProtKB/Swiss-Prot

Q8BG87, Q8CI60

UniProtKB/TrEMBL

A0A8C6IKQ7

Related

ENSMUSP00000139630.2, ENSMUST00000186548.7

Conserved Domains (4) summary

PHA03247
Location:297 → 760

PHA03247; large tegument protein UL36; Provisional

pfam02008
Location:50 → 89

zf-CXXC; CXXC zinc finger domain

cd18897
Location:836 → 1160

TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins

cl40427
Location:1612 → 1774

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
NM_183138.2 → NP_898961.2 methylcytosine dioxygenase TET3 isoform 2

See identical proteins and their annotated locations for NP_898961.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks multiple exons in the coding region, and uses an in-frame downstream start codon, compared to variant 1. Variant 2 encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC090648, AC159713

Consensus CDS

CCDS51820.1

UniProtKB/Swiss-Prot

Q8BG87

UniProtKB/TrEMBL

A0A5K1VVP6, A0A8C6IMQ4

Related

ENSMUSP00000087049.5, ENSMUST00000089622.11

Conserved Domains (1) summary

pfam12851
Location:858 → 985

Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

83339355..83434190 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505776.4 → XP_006505839.1 methylcytosine dioxygenase TET3 isoform X1

See identical proteins and their annotated locations for XP_006505839.1

UniProtKB/Swiss-Prot

Q8BG87, Q8CI60

UniProtKB/TrEMBL

A0A8C6IKQ7

Conserved Domains (4) summary

PHA03247
Location:297 → 760

PHA03247; large tegument protein UL36; Provisional

pfam02008
Location:50 → 89

zf-CXXC; CXXC zinc finger domain

cd18897
Location:836 → 1160

TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins

cl40427
Location:1612 → 1774

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
XM_006505775.4 → XP_006505838.1 methylcytosine dioxygenase TET3 isoform X1

See identical proteins and their annotated locations for XP_006505838.1

UniProtKB/Swiss-Prot

Q8BG87, Q8CI60

UniProtKB/TrEMBL

A0A8C6IKQ7

Conserved Domains (4) summary

PHA03247
Location:297 → 760

PHA03247; large tegument protein UL36; Provisional

pfam02008
Location:50 → 89

zf-CXXC; CXXC zinc finger domain

cd18897
Location:836 → 1160

TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins

cl40427
Location:1612 → 1774

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
XM_006505777.4 → XP_006505840.1 methylcytosine dioxygenase TET3 isoform X2

See identical proteins and their annotated locations for XP_006505840.1

UniProtKB/TrEMBL

K9JH93

Conserved Domains (4) summary

PHA03247
Location:278 → 741

PHA03247; large tegument protein UL36; Provisional

pfam02008
Location:50 → 89

zf-CXXC; CXXC zinc finger domain

cd18897
Location:817 → 1141

TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins

cl40427
Location:1593 → 1755

Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins