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Rasgrp1 RAS guanyl releasing protein 1 [ Mus musculus (house mouse) ]

Gene ID: 19419, updated on 16-Apr-2019

Summary

Official Symbol
Rasgrp1provided by MGI
Official Full Name
RAS guanyl releasing protein 1provided by MGI
Primary source
MGI:MGI:1314635
See related
Ensembl:ENSMUSG00000027347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rasgrp; calDAG-GEFII
Expression
Biased expression in frontal lobe adult (RPKM 49.5), cortex adult (RPKM 48.8) and 5 other tissues See more
Orthologs

Genomic context

See Rasgrp1 in Genome Data Viewer
Location:
2 E5; 2 59.19 cM
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (117279993..117342877, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (117105729..117168613, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RAS related protein 1a, pseudogene 2 Neighboring gene family with sequence similarity 98, member B Neighboring gene predicted gene, 32020 Neighboring gene predicted gene 13982

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (7) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Ras guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
diacylglycerol binding ISO
Inferred from Sequence Orthology
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
activation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of granulocyte macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-gamma secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of natural killer cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
secretory granule localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RAS guanyl-releasing protein 1
Names
calcium and DAG-regulated guanine nucleotide exchange factor II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011246.3NP_035376.1  RAS guanyl-releasing protein 1

    See identical proteins and their annotated locations for NP_035376.1

    Status: VALIDATED

    Source sequence(s)
    BC057341, BE991595
    Consensus CDS
    CCDS16572.1
    UniProtKB/Swiss-Prot
    Q9Z1S3
    Related
    ENSMUSP00000099593.4, ENSMUST00000102534.10
    Conserved Domains (5) summary
    smart00147
    Location:201437
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:54176
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00051
    Location:474521
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:542591
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:478526
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    117279993..117342877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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