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Rasa3 RAS p21 protein activator 3 [ Mus musculus (house mouse) ]

Gene ID: 19414, updated on 13-Oct-2022

Summary

Official Symbol
Rasa3provided by MGI
Official Full Name
RAS p21 protein activator 3provided by MGI
Primary source
MGI:MGI:1197013
See related
Ensembl:ENSMUSG00000031453 AllianceGenome:MGI:1197013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
scat; GAPIII; hlb381; E130011G04
Summary
Predicted to enable calcium-release channel activity. Predicted to be involved in intracellular signal transduction; negative regulation of Ras protein signal transduction; and regulation of GTPase activity. Predicted to act upstream of or within cellular response to heat. Predicted to be intrinsic component of the cytoplasmic side of the plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and neural retina. Used to study aplastic anemia. Orthologous to human RASA3 (RAS p21 protein activator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 50.1), mammary gland adult (RPKM 30.6) and 28 other tissues See more
Orthologs
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Genomic context

See Rasa3 in Genome Data Viewer
Location:
8 A1.1; 8 6.29 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13617218..13727590, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13567218..13677587, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 255B Neighboring gene growth arrest specific 6 Neighboring gene predicted gene, 53399 Neighboring gene RIKEN cDNA 1700029H14 gene Neighboring gene predicted gene, 34795 Neighboring gene VISTA enhancer mm1751 Neighboring gene predicted gene, 46032 Neighboring gene CFAP97 domain containing 2 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
severe combined anemia and thrombocytopenia
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to heat ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras GTPase-activating protein 3
Names
GAP1(IP4BP)
GAPIII activator 3
R-Ras gap
R-ras RTPase activating protein-3
Ras GTPase-activating protein III
ins P4-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009025.2NP_033051.2  ras GTPase-activating protein 3

    See identical proteins and their annotated locations for NP_033051.2

    Status: VALIDATED

    Source sequence(s)
    BC057300, CA749631
    Consensus CDS
    CCDS40234.1
    UniProtKB/Swiss-Prot
    Q60790, Q925V1
    UniProtKB/TrEMBL
    A0A8C6GIC8
    Related
    ENSMUSP00000112998.3, ENSMUST00000117551.4
    Conserved Domains (7) summary
    smart00107
    Location:679714
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:146288
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:13133
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05134
    Location:297565
    RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3
    smart00323
    Location:275614
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13371
    Location:562686
    PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain
    pfam00169
    Location:577676
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13617218..13727590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508734.3XP_006508797.1  ras GTPase-activating protein 3 isoform X1

    Conserved Domains (5) summary
    smart00107
    Location:647682
    BTK; Bruton's tyrosine kinase Cys-rich motif
    cd04010
    Location:114256
    C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
    cd08401
    Location:1101
    C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
    cd05134
    Location:265533
    RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3
    cd13371
    Location:530654
    PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain