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Eme2 essential meiotic structure-specific endonuclease subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 193838, updated on 11-Apr-2024

Summary

Official Symbol
Eme2provided by MGI
Official Full Name
essential meiotic structure-specific endonuclease subunit 2provided by MGI
Primary source
MGI:MGI:1919889
See related
Ensembl:ENSMUSG00000073436 AllianceGenome:MGI:1919889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810013J18Rik
Summary
Predicted to enable DNA binding activity and endonuclease activity. Predicted to be involved in DNA metabolic process and mitotic intra-S DNA damage checkpoint signaling. Predicted to act upstream of or within DNA recombination and cellular response to DNA damage stimulus. Predicted to be located in nucleus. Predicted to be part of Holliday junction resolvase complex. Orthologous to human EME2 (essential meiotic structure-specific endonuclease subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 20.5), genital fat pad adult (RPKM 15.3) and 28 other tissues See more
Orthologs
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Genomic context

See Eme2 in Genome Data Viewer
Location:
17 A3.3; 17 12.53 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25111126..25114061, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24892152..24895087, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41549 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene STARR-positive B cell enhancer ABC_E216 Neighboring gene nucleotide binding protein 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to crossover junction DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
 
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of Holliday junction resolvase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of endodeoxyribonuclease complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear replication fork NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable crossover junction endonuclease EME2
Names
essential meiotic endonuclease 1 homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163102.1NP_001156574.1  probable crossover junction endonuclease EME2

    See identical proteins and their annotated locations for NP_001156574.1

    Status: VALIDATED

    Source sequence(s)
    BC092228, BY148623
    Consensus CDS
    CCDS50023.1
    UniProtKB/Swiss-Prot
    Q56A04
    UniProtKB/TrEMBL
    D3Z6X0
    Related
    ENSMUSP00000113936.2, ENSMUST00000121542.2
    Conserved Domains (1) summary
    pfam02732
    Location:74244
    ERCC4; ERCC4 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25111126..25114061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)