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Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 [ Mus musculus (house mouse) ]

Gene ID: 19378, updated on 2-Apr-2024

Summary

Official Symbol
Aldh1a2provided by MGI
Official Full Name
aldehyde dehydrogenase family 1, subfamily A2provided by MGI
Primary source
MGI:MGI:107928
See related
Ensembl:ENSMUSG00000013584 AllianceGenome:MGI:107928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Raldh1; Raldh2; Aldh1a7
Summary
Enables 3-chloroallyl aldehyde dehydrogenase activity and retinal dehydrogenase activity. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and retinoid metabolic process. Predicted to be located in cytosol and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study DiGeorge syndrome. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 26.6), subcutaneous fat pad adult (RPKM 13.9) and 20 other tissues See more
Orthologs
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Genomic context

See Aldh1a2 in Genome Data Viewer
Location:
9 D; 9 39.85 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (71123071..71203525)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (71215789..71296243)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24566 Neighboring gene STARR-seq mESC enhancer starr_24567 Neighboring gene predicted gene, 32511 Neighboring gene STARR-seq mESC enhancer starr_24568 Neighboring gene STARR-seq mESC enhancer starr_24569 Neighboring gene predicted gene 3458 Neighboring gene STARR-seq mESC enhancer starr_24571 Neighboring gene predicted gene, 32769 Neighboring gene STARR-seq mESC enhancer starr_24572 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide M

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables retinal binding ISO
Inferred from Sequence Orthology
more info
 
enables retinal dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within determination of bilateral symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic camera-type eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within face development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within face development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development TAS
Traceable Author Statement
more info
PubMed 
involved_in heart looping TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hindbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural crest cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural crest cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural tube development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of vascular endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retinal metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinoic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retinoic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within retinoic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retinoic acid receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within retinoic acid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retinoic acid receptor signaling pathway involved in somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within retinoic acid receptor signaling pathway involved in somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinoid metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within ureter maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
retinal dehydrogenase 2
Names
RALDH 2
RALDH(II)
alcohol dehydrogenase family 1, subfamily A2
alcohol dehydrogenase family 1, subfamily A7
aldehyde dehydrogenase family 1 member A2
retinaldehyde dehydrogenase 2
retinaldehyde-specific dehydrogenase type 2
NP_033048.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009022.4NP_033048.2  retinal dehydrogenase 2

    See identical proteins and their annotated locations for NP_033048.2

    Status: VALIDATED

    Source sequence(s)
    AK078553, BC075704, CJ166631
    Consensus CDS
    CCDS52852.1
    UniProtKB/Swiss-Prot
    Q62148, Q6DI79
    Related
    ENSMUSP00000034723.6, ENSMUST00000034723.6
    Conserved Domains (1) summary
    cd07141
    Location:32512
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    71123071..71203525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)