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Rai1 retinoic acid induced 1 [ Mus musculus (house mouse) ]

Gene ID: 19377, updated on 30-Oct-2022

Summary

Official Symbol
Rai1provided by MGI
Official Full Name
retinoic acid induced 1provided by MGI
Primary source
MGI:MGI:103291
See related
Ensembl:ENSMUSG00000062115 AllianceGenome:MGI:103291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gt1
Summary
Predicted to enable metal ion binding activity. Involved in circadian regulation of gene expression. Acts upstream of or within regulation of growth; regulation of transcription by RNA polymerase II; and skeletal system development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb bud; and sensory organ. Used to study Potocki-Lupski syndrome and Smith-Magenis syndrome. Human ortholog(s) of this gene implicated in Smith-Magenis syndrome. Orthologous to human RAI1 (retinoic acid induced 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 23.6), adrenal adult (RPKM 10.9) and 25 other tissues See more
Orthologs
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Genomic context

See Rai1 in Genome Data Viewer
Location:
11; 11 B1.3- B2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59995743..60090023)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60104917..60199197)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine N-methyltransferase Neighboring gene predicted gene, 53709 Neighboring gene predicted gene, 38498 Neighboring gene RIKEN cDNA 4930412M03 gene Neighboring gene predicted gene, 53710 Neighboring gene microRNA 6921 Neighboring gene microRNA 6922 Neighboring gene sterol regulatory element binding transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
retinoic acid-induced protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037764.1NP_001032853.1  retinoic acid-induced protein 1

    See identical proteins and their annotated locations for NP_001032853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL669954, AY548172
    Consensus CDS
    CCDS24784.1
    UniProtKB/Swiss-Prot
    Q61818, Q8CEV1
    UniProtKB/TrEMBL
    Q5QGZ6
    Related
    ENSMUSP00000126183.2, ENSMUST00000171108.8
    Conserved Domains (2) summary
    PHA03247
    Location:9391375
    PHA03247; large tegument protein UL36; Provisional
    cl22851
    Location:16551884
    PHD_SF; PHD finger superfamily
  2. NM_009021.2NP_033047.2  retinoic acid-induced protein 1

    See identical proteins and their annotated locations for NP_033047.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK154252, AL669954, BC049785
    Consensus CDS
    CCDS24784.1
    UniProtKB/Swiss-Prot
    Q61818, Q8CEV1
    UniProtKB/TrEMBL
    Q810L5
    Related
    ENSMUSP00000070896.7, ENSMUST00000064190.13
    Conserved Domains (2) summary
    PHA03247
    Location:9391375
    PHA03247; large tegument protein UL36; Provisional
    cl22851
    Location:16551884
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    59995743..60090023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156456.1XP_036012349.1  retinoic acid-induced protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8CEV1
    Related
    ENSMUSP00000099749.2, ENSMUST00000102688.2
    Conserved Domains (2) summary
    PHA03247
    Location:9391375
    PHA03247; large tegument protein UL36; Provisional
    cl22851
    Location:16551884
    PHD_SF; PHD finger superfamily

RNA

  1. XR_004936881.1 RNA Sequence

  2. XR_879537.3 RNA Sequence

  3. XR_004936878.1 RNA Sequence

  4. XR_004936879.1 RNA Sequence

  5. XR_004936880.1 RNA Sequence

  6. XR_879538.3 RNA Sequence

  7. XR_004936875.1 RNA Sequence

  8. XR_003949361.2 RNA Sequence

  9. XR_004936877.1 RNA Sequence

  10. XR_879539.4 RNA Sequence