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Rab34 RAB34, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19376, updated on 8-Dec-2022

Summary

Official Symbol
Rab34provided by MGI
Official Full Name
RAB34, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:104606
See related
Ensembl:ENSMUSG00000002059 AllianceGenome:MGI:104606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rah; Narr; Rah1
Summary
Enables GTPase activity and guanyl nucleotide binding activity. Involved in several processes, including Golgi to plasma membrane protein transport; phagosome-lysosome fusion; and positive regulation of protein localization to phagocytic vesicle. Acts upstream of or within endocytosis. Located in Golgi apparatus; endosome; and ruffle. Colocalizes with phagocytic vesicle. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human RAB34 (RAB34, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 68.8), ovary adult (RPKM 45.7) and 20 other tissues See more
Orthologs
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Genomic context

See Rab34 in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78079253..78083019)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78188427..78192193)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 4A Neighboring gene ribosomal protein L23A Neighboring gene small nucleolar RNA, C/D box 42B Neighboring gene Rab34 Hedgehog-responsive enhancer Neighboring gene protein interacting with cyclin A1 Neighboring gene SPT6, histone chaperone and transcription elongation factor Neighboring gene stromal cell derived factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl nucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Golgi to plasma membrane protein transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lysosomal transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
 
involved_in phagosome maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in phagosome-lysosome fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagosome-lysosome fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to phagocytic vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Golgi cisterna IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rab-34
Names
RAB34, member of RAS oncogene family
rab-39
ras-related homolog
ras-related protein Rab-39
ras-related protein Rah

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159482.1NP_001152954.1  ras-related protein Rab-34

    See identical proteins and their annotated locations for NP_001152954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA041780, AB082927, AF327929, AV142766, BY317641
    Consensus CDS
    CCDS25094.1
    UniProtKB/Swiss-Prot
    Q64008
    UniProtKB/TrEMBL
    Q0PD20
    Related
    ENSMUSP00000002128.8, ENSMUST00000002128.14
    Conserved Domains (2) summary
    smart00175
    Location:54213
    RAB; Rab subfamily of small GTPases
    cd04108
    Location:53220
    Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)
  2. NM_033475.3NP_258436.2  ras-related protein Rab-34

    See identical proteins and their annotated locations for NP_258436.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB082927, AV142766, BB643883, BY195955, BY234941
    Consensus CDS
    CCDS25094.1
    UniProtKB/Swiss-Prot
    Q64008
    UniProtKB/TrEMBL
    Q0PD20
    Related
    ENSMUSP00000103958.3, ENSMUST00000108322.9
    Conserved Domains (2) summary
    smart00175
    Location:54213
    RAB; Rab subfamily of small GTPases
    cd04108
    Location:53220
    Rab36_Rab34; Rab GTPase families 34 (Rab34) and 36 (Rab36)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78079253..78083019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)