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EEF1G eukaryotic translation elongation factor 1 gamma [ Homo sapiens (human) ]

Gene ID: 1937, updated on 3-May-2020

Summary

Official Symbol
EEF1Gprovided by HGNC
Official Full Name
eukaryotic translation elongation factor 1 gammaprovided by HGNC
Primary source
HGNC:HGNC:3213
See related
Ensembl:ENSG00000254772 MIM:130593
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EF1G; GIG35
Summary
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1189.4), lymph node (RPKM 694.2) and 25 other tissues See more
Orthologs

Genomic context

See EEF1G in Genome Data Viewer
Location:
11q12.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62559596..62573891, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62327073..62341460, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723765 Neighboring gene secretoglobin family 1A member 1 Neighboring gene AHNAK nucleoprotein Neighboring gene microRNA 6747 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene metastasis associated 1 family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein translational elongation factor 1 PubMed
nef Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
integrase gag-pol HIV-1 IN co-immunoprecipitates with eEF1G through an interaction with the viral RTCs PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation elongation factor 1 gamma (EEF1G) at amino acid residues 20-21 by the HIV-1 protease PubMed
reverse transcriptase p51 subunit gag-pol HIV-1 RT p51 subunit co-immunoprecipitates with eEF1A through an interaction with the viral RTCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational elongation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
elongation factor 1-gamma
Names
EF-1-gamma
PRO1608
eEF-1B gamma
pancreatic tumor-related protein
translation elongation factor eEF-1 gamma chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404.5NP_001395.1  elongation factor 1-gamma

    See identical proteins and their annotated locations for NP_001395.1

    Status: REVIEWED

    Source sequence(s)
    AP001363, BC028179, BQ947806, X63526
    Consensus CDS
    CCDS44626.1
    UniProtKB/Swiss-Prot
    P26641
    UniProtKB/TrEMBL
    Q53YD7
    Related
    ENSP00000331901.4, ENST00000329251.5
    Conserved Domains (4) summary
    cd03181
    Location:91213
    GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
    cd03044
    Location:482
    GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
    pfam00647
    Location:277381
    EF1G; Elongation factor 1 gamma, conserved domain
    cl25545
    Location:212278
    V-ATPase_G_2; Vacuolar (H+)-ATPase G subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62559596..62573891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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