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Rad23a RAD23 homolog A, nucleotide excision repair protein [ Mus musculus (house mouse) ]

Gene ID: 19358, updated on 18-Apr-2024

Summary

Official Symbol
Rad23aprovided by MGI
Official Full Name
RAD23 homolog A, nucleotide excision repair proteinprovided by MGI
Primary source
MGI:MGI:105126
See related
Ensembl:ENSMUSG00000003813 AllianceGenome:MGI:105126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HR23A; mHR23A; 2310040P19Rik
Summary
Predicted to enable several functions, including enzyme binding activity; proteasome binding activity; and ubiquitin binding activity. Acts upstream of or within cellular response to DNA damage stimulus. Predicted to be located in centriolar satellite; cytoplasm; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleoplasm. Is expressed in brain and liver. Orthologous to human RAD23A (RAD23 homolog A, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 50.1), liver E14 (RPKM 45.7) and 28 other tissues See more
Orthologs
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Genomic context

Location:
8 C3; 8 41.2 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85561540..85567361, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84834927..84840652, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA G430095P16 gene Neighboring gene nuclear factor I/X Neighboring gene VISTA enhancer mm21 Neighboring gene VISTA enhancer mm1615 Neighboring gene STARR-seq mESC enhancer starr_22139 Neighboring gene DAN domain family member 5, BMP antagonist Neighboring gene growth arrest and DNA-damage-inducible, gamma interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E5027 Neighboring gene RIKEN cDNA 1700122E12 gene Neighboring gene STARR-positive B cell enhancer ABC_E564 Neighboring gene calreticulin Neighboring gene predicted gene 5911

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
UV excision repair protein RAD23 homolog A
Names
RAD23a homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297606.2NP_001284535.1  UV excision repair protein RAD23 homolog A isoform 1

    See identical proteins and their annotated locations for NP_001284535.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC155163
    Consensus CDS
    CCDS80908.1
    UniProtKB/Swiss-Prot
    B7ZNQ1, P54726
    Related
    ENSMUSP00000105383.3, ENSMUST00000109761.9
    Conserved Domains (5) summary
    cd01805
    Location:380
    RAD23_N; Ubiquitin-like domain of RAD23
    cd14377
    Location:162201
    UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa
    cd14427
    Location:319359
    UBA2_HR23A; UBA2 domain of UV excision repair protein RAD23 homolog A (HR23A) found in vertebrates
    TIGR00601
    Location:3361
    rad23; UV excision repair protein Rad23
    pfam09280
    Location:232287
    XPC-binding; XPC-binding domain
  2. NM_001297607.2NP_001284536.1  UV excision repair protein RAD23 homolog A isoform 3

    See identical proteins and their annotated locations for NP_001284536.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC155163
    UniProtKB/TrEMBL
    Q3TN85
    Related
    ENSMUSP00000115664.2, ENSMUST00000128035.2
    Conserved Domains (4) summary
    cd01805
    Location:380
    RAD23_N; Ubiquitin-like domain of RAD23
    smart00213
    Location:377
    UBQ; Ubiquitin homologues
    cd14377
    Location:162201
    UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa
    pfam09280
    Location:232287
    XPC-binding; XPC-binding domain
  3. NM_001378894.1NP_001365823.1  UV excision repair protein RAD23 homolog A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC155163
    Conserved Domains (1) summary
    TIGR00601
    Location:3365
    rad23; UV excision repair protein Rad23
  4. NM_001378895.1NP_001365824.1  UV excision repair protein RAD23 homolog A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC155163
    Conserved Domains (1) summary
    TIGR00601
    Location:3364
    rad23; UV excision repair protein Rad23
  5. NM_001378896.1NP_001365825.1  UV excision repair protein RAD23 homolog A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC155163
    UniProtKB/TrEMBL
    Q8BRA9
    Conserved Domains (1) summary
    TIGR00601
    Location:3286
    rad23; UV excision repair protein Rad23
  6. NM_009010.6NP_033036.2  UV excision repair protein RAD23 homolog A isoform 2

    See identical proteins and their annotated locations for NP_033036.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC155163
    Consensus CDS
    CCDS40414.1
    UniProtKB/TrEMBL
    Q8CAP3
    Related
    ENSMUSP00000003911.7, ENSMUST00000003911.13
    Conserved Domains (5) summary
    cd01805
    Location:380
    RAD23_N; Ubiquitin-like domain of RAD23
    cd14377
    Location:162201
    UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa
    cd14427
    Location:318358
    UBA2_HR23A; UBA2 domain of UV excision repair protein RAD23 homolog A (HR23A) found in vertebrates
    TIGR00601
    Location:3360
    rad23; UV excision repair protein Rad23
    pfam09280
    Location:231286
    XPC-binding; XPC-binding domain

RNA

  1. NR_166165.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC155163
  2. NR_166166.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC155163

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85561540..85567361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004934782.1 RNA Sequence

  2. XR_004934781.1 RNA Sequence

  3. XR_004934783.1 RNA Sequence