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Rad21 RAD21 cohesin complex component [ Mus musculus (house mouse) ]

Gene ID: 19357, updated on 6-Dec-2022

Summary

Official Symbol
Rad21provided by MGI
Official Full Name
RAD21 cohesin complex componentprovided by MGI
Primary source
MGI:MGI:108016
See related
Ensembl:ENSMUSG00000022314 AllianceGenome:MGI:108016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SCC1; mHR21; mKIAA0078
Summary
Predicted to enable chromatin binding activity. Involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of mitotic metaphase/anaphase transition. Located in chromatin; chromosome, centromeric region; and condensed nuclear chromosome. Part of cohesin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human RAD21 (RAD21 cohesin complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 53.2), liver E14 (RPKM 45.0) and 24 other tissues See more
Orthologs
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Genomic context

See Rad21 in Genome Data Viewer
Location:
15; 15 C
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (51826000..51856934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (51962604..51993538, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene UTP23 small subunit processome component Neighboring gene predicted gene, 34678 Neighboring gene predicted gene, 48923 Neighboring gene predicted gene, 52217 Neighboring gene protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene Neighboring gene alanine and arginine rich domain containing protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150311, MGC150312

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitotic metaphase/anaphase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in replication-born double-strand break repair via sister chromatid exchange IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
part_of cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cohesin complex ISO
Inferred from Sequence Orthology
more info
 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
double-strand-break repair protein rad21 homolog
Names
PW29
RAD21 homolog
SCC1 homolog
pokeweed agglutinin-binding protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411716.1NP_001398645.1  double-strand-break repair protein rad21 homolog

    Status: VALIDATED

    Source sequence(s)
    AC160550
    UniProtKB/Swiss-Prot
    Q9DBU4
  2. NM_009009.5NP_033035.3  double-strand-break repair protein rad21 homolog

    See identical proteins and their annotated locations for NP_033035.3

    Status: VALIDATED

    Source sequence(s)
    AC160550
    Consensus CDS
    CCDS27463.1
    UniProtKB/Swiss-Prot
    Q61550, Q9DBU4
    UniProtKB/TrEMBL
    Q3TG35
    Related
    ENSMUSP00000022927.10, ENSMUST00000022927.11
    Conserved Domains (2) summary
    pfam04824
    Location:578632
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1104
    Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    51826000..51856934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520644.1XP_006520707.1  double-strand-break repair protein rad21 homolog isoform X1

    See identical proteins and their annotated locations for XP_006520707.1

    UniProtKB/Swiss-Prot
    Q61550, Q9DBU4
    Conserved Domains (2) summary
    pfam04824
    Location:578632
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1104
    Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein
  2. XM_006520645.2XP_006520708.1  double-strand-break repair protein rad21 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q61550
    Conserved Domains (2) summary
    pfam04824
    Location:578632
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1104
    Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein