U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rab4b RAB4B, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19342, updated on 12-May-2024

Summary

Official Symbol
Rab4bprovided by MGI
Official Full Name
RAB4B, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:105071
See related
Ensembl:ENSMUSG00000053291 AllianceGenome:MGI:105071
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500031G17Rik
Summary
Predicted to enable G protein activity and GTP binding activity. Predicted to be involved in glucose import and regulation of endocytosis. Predicted to act upstream of or within protein transport. Located in mitochondrion. Is expressed in nasal septum and skeleton. Orthologous to human RAB4B (RAB4B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 39.5), cerebellum adult (RPKM 38.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rab4b in Genome Data Viewer
Location:
7 A3; 7 15.84 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26867858..26878308, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27168433..27178883, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily t, polypeptide 4 Neighboring gene egl-9 family hypoxia-inducible factor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr7:27952094-27952395 Neighboring gene STARR-positive B cell enhancers ABC_E1725 and ABC_E288 Neighboring gene microRNA 3101 Neighboring gene MIA SH3 domain containing Neighboring gene small nuclear ribonucleoprotein polypeptide A Neighboring gene STARR-positive B cell enhancer ABC_E3707 Neighboring gene actin maturation protease

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Mia

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Rab protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in insulin-responsive compartment IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in insulin-responsive compartment ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rab-4B
NP_083667.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029391.2NP_083667.1  ras-related protein Rab-4B

    See identical proteins and their annotated locations for NP_083667.1

    Status: PROVISIONAL

    Source sequence(s)
    AC157553
    Consensus CDS
    CCDS21012.1
    UniProtKB/Swiss-Prot
    Q91ZR1
    UniProtKB/TrEMBL
    Q3USC3, Q4V9W8
    Related
    ENSMUSP00000090727.7, ENSMUST00000093040.13
    Conserved Domains (1) summary
    cd04113
    Location:9169
    Rab4; Rab GTPase family 4 (Rab4)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    26867858..26878308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)