Rab4b RAB4B, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab4bprovided by MGI
Official Full Name: RAB4B, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:105071
See related: Ensembl:ENSMUSG00000053291 AllianceGenome:MGI:105071
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1500031G17Rik
Summary: Predicted to enable G protein activity and GTP binding activity. Predicted to be involved in glucose import and regulation of endocytosis. Predicted to act upstream of or within protein transport. Located in mitochondrion. Is expressed in nasal septum and skeleton. Orthologous to human RAB4B (RAB4B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 39.5), cerebellum adult (RPKM 38.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 15.84 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (26867858..26878308, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (27168433..27178883, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the obesity-induced loss of Rab4b in adipose T cells may contribute to maladaptive white adipose tissue remodeling and insulin resistance by altering adipose T cell fate.
Title: Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance.
Data conclude that Rab4b is a new important player in the control of GLUT4 trafficking in adipocyte.
Title: Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Rab4b gene: The Rab4b gene is conserved in human, dog, cow, rat, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 257 organisms have orthologs with human gene Rab4b
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in insulin-responsive compartment	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-4B

NP_083667.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.