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Rab4a RAB4A, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19341, updated on 8-Feb-2024

Summary

Official Symbol
Rab4aprovided by MGI
Official Full Name
RAB4A, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:105069
See related
Ensembl:ENSMUSG00000019478 AllianceGenome:MGI:105069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab4
Summary
Predicted to enable several functions, including ATPase binding activity; guanyl ribonucleotide binding activity; and ionotropic glutamate receptor binding activity. Acts upstream of or within protein transport; regulation of endocytosis; and small GTPase mediated signal transduction. Located in endosome. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and liver and biliary system. Orthologous to human RAB4A (RAB4A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 26.3), cerebellum adult (RPKM 22.2) and 28 other tissues See more
Orthologs
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Genomic context

See Rab4a in Genome Data Viewer
Location:
8 E2; 8 72.19 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124532748..124562030)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123805846..123835291)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732419C18 gene Neighboring gene predicted gene, 36188 Neighboring gene STARR-seq mESC enhancer starr_22987 Neighboring gene centriole, cilia and spindle associated protein Neighboring gene STARR-positive B cell enhancer ABC_E5049 Neighboring gene predicted gene 4342 Neighboring gene predicted gene 9901

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in insulin-responsive compartment IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in insulin-responsive compartment ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rab-4A
NP_033029.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009003.5NP_033029.2  ras-related protein Rab-4A

    See identical proteins and their annotated locations for NP_033029.2

    Status: VALIDATED

    Source sequence(s)
    AC147266, AEKQ02169250
    Consensus CDS
    CCDS52703.1
    UniProtKB/Swiss-Prot
    P56371, Q3TSQ6
    UniProtKB/TrEMBL
    Q3ULK1
    Related
    ENSMUSP00000113886.2, ENSMUST00000118535.9
    Conserved Domains (1) summary
    cd04113
    Location:14174
    Rab4; Rab GTPase family 4 (Rab4)

RNA

  1. NR_188946.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC147266, AEKQ02169250

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124532748..124562030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)