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EEF1B2 eukaryotic translation elongation factor 1 beta 2 [ Homo sapiens (human) ]

Gene ID: 1933, updated on 13-May-2022

Summary

Official Symbol
EEF1B2provided by HGNC
Official Full Name
eukaryotic translation elongation factor 1 beta 2provided by HGNC
Primary source
HGNC:HGNC:3208
See related
Ensembl:ENSG00000114942 MIM:600655; AllianceGenome:HGNC:3208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EF1B; EEF1B; EEF1B1
Summary
This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 282.5), lymph node (RPKM 249.8) and 25 other tissues See more
Orthologs
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Genomic context

See EEF1B2 in Genome Data Viewer
Location:
2q33.3
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (206159609..206162928)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (206641502..206644822)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207024333..207027652)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene INO80 complex subunit D Neighboring gene Sharpr-MPRA regulatory region 7917 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S1 Neighboring gene glycine cleavage system protein H pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 51 Neighboring gene small nucleolar RNA, H/ACA box 41 Neighboring gene chemerin chemokine-like receptor 2 Neighboring gene CMKLR2 antisense RNA Neighboring gene RN7SK pseudogene 200

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation elongation factor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translational elongation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic translation elongation factor 1 complex NAS
Non-traceable Author Statement
more info
PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
elongation factor 1-beta
Names
EF-1-beta
eukaryotic translation elongation factor 1 beta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037663.2NP_001032752.1  elongation factor 1-beta

    See identical proteins and their annotated locations for NP_001032752.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a distinct 5' UTR compared to variants 1 and 2. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BM747256, BU565415, BU627453
    Consensus CDS
    CCDS2367.1
    UniProtKB/Swiss-Prot
    P24534
    UniProtKB/TrEMBL
    A0A024R3W7
    Related
    ENSP00000376055.1, ENST00000392221.5
    Conserved Domains (3) summary
    cd10308
    Location:362
    GST_C_eEF1b_like; Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
    pfam00736
    Location:142225
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:103130
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  2. NM_001959.4NP_001950.1  elongation factor 1-beta

    See identical proteins and their annotated locations for NP_001950.1

    Status: REVIEWED

    Description
    Transcript Variant: This predominant variant (1) has a distinct 5' UTR. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    X60489
    Consensus CDS
    CCDS2367.1
    UniProtKB/Swiss-Prot
    P24534
    UniProtKB/TrEMBL
    A0A024R3W7
    Related
    ENSP00000376056.2, ENST00000392222.7
    Conserved Domains (3) summary
    cd10308
    Location:362
    GST_C_eEF1b_like; Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
    pfam00736
    Location:142225
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:103130
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
  3. NM_021121.4NP_066944.1  elongation factor 1-beta

    See identical proteins and their annotated locations for NP_066944.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct 5' UTR compared to variants 1 and 3. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BU565415, BU627453, X60656
    Consensus CDS
    CCDS2367.1
    UniProtKB/Swiss-Prot
    P24534
    UniProtKB/TrEMBL
    A0A024R3W7
    Related
    ENSP00000236957.5, ENST00000236957.9
    Conserved Domains (3) summary
    cd10308
    Location:362
    GST_C_eEF1b_like; Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
    pfam00736
    Location:142225
    EF1_GNE; EF-1 guanine nucleotide exchange domain
    pfam10587
    Location:103130
    EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    206159609..206162928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_015495299.1 Reference GRCh38.p14 PATCHES

    Range
    268627..271946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    206641502..206644822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)