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Rab10 RAB10, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19325, updated on 18-Sep-2024

Summary

Official Symbol
Rab10provided by MGI
Official Full Name
RAB10, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:105066
See related
Ensembl:ENSMUSG00000020671 AllianceGenome:MGI:105066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GDP-dissociation inhibitor binding activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in cellular response to insulin stimulus; protein localization to plasma membrane; and vesicle-mediated transport. Located in Golgi apparatus; cilium; and perinuclear region of cytoplasm. Is expressed in embryo. Orthologous to human RAB10 (RAB10, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 55.0), bladder adult (RPKM 47.9) and 28 other tissues See more
Orthologs
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Genomic context

See Rab10 in Genome Data Viewer
Location:
12 A1.1; 12 1.71 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (3297428..3359969, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (3247428..3309969, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene NLR family, pyrin domain containing 2 pseudogene Neighboring gene NLR family, pyrin domain containing 5 pseudogene Neighboring gene RAB10, member RAS oncogene family, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:3310165-3310274 Neighboring gene STARR-seq mESC enhancer starr_31404 Neighboring gene STARR-seq mESC enhancer starr_31405 Neighboring gene STARR-seq mESC enhancer starr_31406 Neighboring gene STARR-positive B cell enhancer ABC_E10738 Neighboring gene predicted gene, 26520 Neighboring gene STARR-positive B cell enhancer ABC_E9852 Neighboring gene RIKEN cDNA I920046F24 gene Neighboring gene kinesin family member 3C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GDP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GDP-dissociation inhibitor binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GTPase activity TAS
Traceable Author Statement
more info
 
enables myosin V binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables myosin V binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin V binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Golgi to plasma membrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in Golgi to plasma membrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
 
involved_in antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
 
involved_in axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum tubular network organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of neuroblast polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of neuroblast polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of protein localization to endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization to endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
PubMed 
involved_in polarized epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulated exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum tubular network ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of exocyst ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in exocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in insulin-responsive compartment ISO
Inferred from Sequence Orthology
more info
 
located_in insulin-responsive compartment ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in secretory vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ras-related protein Rab-10
NP_057885.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016676.5NP_057885.1  ras-related protein Rab-10

    See identical proteins and their annotated locations for NP_057885.1

    Status: VALIDATED

    Source sequence(s)
    AK028320, BC052735, CJ092612
    Consensus CDS
    CCDS25782.1
    UniProtKB/Swiss-Prot
    P61027
    UniProtKB/TrEMBL
    Q3U621, Q4FJL0
    Related
    ENSMUSP00000021001.9, ENSMUST00000021001.10
    Conserved Domains (1) summary
    cd01867
    Location:7173
    Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    3297428..3359969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)