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Qki quaking, KH domain containing RNA binding [ Mus musculus (house mouse) ]

Gene ID: 19317, updated on 5-Jan-2023

Summary

Official Symbol
Qkiprovided by MGI
Official Full Name
quaking, KH domain containing RNA bindingprovided by MGI
Primary source
MGI:MGI:97837
See related
Ensembl:ENSMUSG00000062078 AllianceGenome:MGI:97837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Qk; l17Wis1; 1500005P18; l(17)-1Wis; 1110003F05Rik
Summary
Enables mRNA binding activity. Acts upstream of or within several processes, including long-chain fatty acid biosynthetic process; positive regulation of macromolecule metabolic process; and vasculogenesis. Located in cytoplasm; nucleus; and synapse. Is expressed in several structures, including alimentary system; central nervous system; craniocervical region bone; reproductive system; and sensory organ. Orthologous to human QKI (QKI, KH domain containing RNA binding). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 30.8), cerebellum adult (RPKM 26.6) and 23 other tissues See more
Orthologs
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Genomic context

See Qki in Genome Data Viewer
Location:
17 A1; 17 7.75 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (10425400..10538706, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (10206471..10319361, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34799 Neighboring gene predicted gene, 34972 Neighboring gene RIKEN cDNA 1700110C19 gene Neighboring gene predicted gene, 46608 Neighboring gene colon adenocarcinoma hypermethylated RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within axon ensheathment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatid development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within vascular associated smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
KH domain-containing RNA-binding protein QKI; protein quaking
Names
QKI-5 protein
QKI-6 protein
QKI-7 protein
QKI-7b protein
lethal, Chr 17, U Wisconsin 1
quaking

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159516.2NP_001152988.1  KH domain-containing RNA-binding protein QKI isoform 2

    See identical proteins and their annotated locations for NP_001152988.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC113114, AC154238
    Consensus CDS
    CCDS88989.1
    UniProtKB/Swiss-Prot
    Q9QYS9
    UniProtKB/TrEMBL
    A0A6P5R944
    Related
    ENSMUSP00000156665.2, ENSMUST00000233828.2
    Conserved Domains (3) summary
    PRK14951
    Location:210281
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    pfam16544
    Location:1066
    STAR_dimer; Homodimerization region of STAR domain protein
    cd22465
    Location:81183
    KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
  2. NM_001159517.2NP_001152989.1  KH domain-containing RNA-binding protein QKI isoform 1

    See identical proteins and their annotated locations for NP_001152989.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC113114, AC154238
    Consensus CDS
    CCDS49947.1
    UniProtKB/Swiss-Prot
    Q9QYS9, Q9Z246
    UniProtKB/TrEMBL
    A0A6P5RFB4
    Related
    ENSMUSP00000156511.2, ENSMUST00000233645.2
    Conserved Domains (4) summary
    PHA03247
    Location:211314
    PHA03247; large tegument protein UL36; Provisional
    pfam16544
    Location:1066
    STAR_dimer; Homodimerization region of STAR domain protein
    pfam16551
    Location:312341
    Quaking_NLS; Putative nuclear localization signal of quaking
    cd22465
    Location:81183
    KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
  3. NM_021881.3NP_068681.1  KH domain-containing RNA-binding protein QKI isoform 3

    See identical proteins and their annotated locations for NP_068681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC113114, AC154238
    Consensus CDS
    CCDS28387.1
    UniProtKB/Swiss-Prot
    Q9QYS9
    UniProtKB/TrEMBL
    A0A6P5RCB9
    Related
    ENSMUSP00000046740.8, ENSMUST00000042296.9
    Conserved Domains (3) summary
    PRK14951
    Location:210281
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    pfam16544
    Location:1066
    STAR_dimer; Homodimerization region of STAR domain protein
    cd22465
    Location:81183
    KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    10425400..10538706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523300.4XP_006523363.1  protein quaking isoform X1

    See identical proteins and their annotated locations for XP_006523363.1

    UniProtKB/TrEMBL
    A0A6P5R9R6
    Conserved Domains (4) summary
    PRK14950
    Location:195305
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
    pfam16544
    Location:1066
    STAR_dimer; Homodimerization region of STAR domain protein
    pfam16551
    Location:304333
    Quaking_NLS; Putative nuclear localization signal of quaking
    cd22465
    Location:81183
    KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
  2. XM_030249598.2XP_030105458.1  protein quaking isoform X2

    Conserved Domains (3) summary
    PRK14971
    Location:182311
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam16544
    Location:1066
    STAR_dimer; Homodimerization region of STAR domain protein
    cd22465
    Location:81183
    KH-I_Hqk; type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins

RNA

  1. XR_385167.4 RNA Sequence

  2. XR_385168.4 RNA Sequence

  3. XR_385170.4 RNA Sequence

  4. XR_385169.4 RNA Sequence