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Pex5 peroxisomal biogenesis factor 5 [ Mus musculus (house mouse) ]

Gene ID: 19305, updated on 8-Feb-2024

Summary

Official Symbol
Pex5provided by MGI
Official Full Name
peroxisomal biogenesis factor 5provided by MGI
Primary source
MGI:MGI:1098808
See related
Ensembl:ENSMUSG00000005069 AllianceGenome:MGI:1098808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pxr1; ESTM1; PTS1R; PXR1P; PTS1-BP
Summary
Predicted to enable several functions, including peroxisome targeting sequence binding activity; protein C-terminus binding activity; and protein sequestering activity. Involved in protein import into peroxisome matrix. Acts upstream of or within several processes, including fatty acid metabolic process; mitochondrial membrane organization; and nervous system development. Predicted to be located in Golgi apparatus; membrane; and peroxisomal matrix. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and peroxisomal membrane. Is expressed in genitourinary system; inner ear; liver; and nervous system. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Orthologous to human PEX5 (peroxisomal biogenesis factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 17.6), subcutaneous fat pad adult (RPKM 13.2) and 28 other tissues See more
Orthologs
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Genomic context

See Pex5 in Genome Data Viewer
Location:
6 F2; 6 59.15 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124373774..124392878, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124396816..124415944, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700013D24 gene Neighboring gene RIKEN cDNA 1700027F06 gene Neighboring gene RIKEN cDNA D830015G05 gene Neighboring gene STARR-positive B cell enhancer ABC_E3680 Neighboring gene calsyntenin 3 Neighboring gene predicted gene, 44096 Neighboring gene complement component 1, r subcomponent-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables peroxisome matrix targeting signal-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peroxisome matrix targeting signal-1 binding ISO
Inferred from Sequence Orthology
more info
 
enables peroxisome matrix targeting signal-1 binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables peroxisome membrane targeting sequence binding ISO
Inferred from Sequence Orthology
more info
 
enables peroxisome targeting sequence binding ISO
Inferred from Sequence Orthology
more info
 
enables peroxisome targeting sequence binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein carrier chaperone ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebral cortex cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within isoprenoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrial membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peroxisome organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peroxisome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pexophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import into peroxisome matrix IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import into peroxisome matrix ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into peroxisome matrix, docking IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein import into peroxisome matrix, docking ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into peroxisome matrix, receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into peroxisome matrix, substrate release ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into peroxisome matrix, translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into peroxisome membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to peroxisome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within protein targeting to peroxisome TAS
Traceable Author Statement
more info
PubMed 
involved_in protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within very long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisomal targeting signal 1 receptor
Names
PTS1 receptor
peroxin 5
peroxisomal C-terminal targeting signal import receptor
peroxisome biogenesis factor 5
peroxisome receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277330.2NP_001264259.1  peroxisomal targeting signal 1 receptor isoform 2

    See identical proteins and their annotated locations for NP_001264259.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 2 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AC124470
    Consensus CDS
    CCDS20518.1
    UniProtKB/Swiss-Prot
    O09012
    Related
    ENSMUSP00000108150.2, ENSMUST00000112531.8
    Conserved Domains (2) summary
    sd00006
    Location:451479
    TPR; TPR repeat [structural motif]
    cl26002
    Location:311546
    TPR_11; TPR repeat
  2. NM_001277805.2NP_001264734.1  peroxisomal targeting signal 1 receptor isoform 1

    See identical proteins and their annotated locations for NP_001264734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 5, 7, and 8 all encode the same isoform (1).
    Source sequence(s)
    AC124470
    Consensus CDS
    CCDS20517.1
    UniProtKB/Swiss-Prot
    O09012, Q3UM58, Q8K2V5, Q91YC7
    Related
    ENSMUSP00000049132.6, ENSMUST00000035861.6
    Conserved Domains (3) summary
    TIGR02917
    Location:348583
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:488516
    TPR; TPR repeat [structural motif]
    cl02686
    Location:307342
    PRY; SPRY-associated domain
  3. NM_001360570.2NP_001347499.1  peroxisomal targeting signal 1 receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124470
    Consensus CDS
    CCDS20518.1
    Conserved Domains (2) summary
    sd00006
    Location:451479
    TPR; TPR repeat [structural motif]
    cl26002
    Location:311546
    TPR_11; TPR repeat
  4. NM_001410279.1NP_001397208.1  peroxisomal targeting signal 1 receptor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124470
    UniProtKB/Swiss-Prot
    O09012, Q3UM58, Q8K2V5, Q91YC7
  5. NM_001410280.1NP_001397209.1  peroxisomal targeting signal 1 receptor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124470
    UniProtKB/Swiss-Prot
    O09012, Q3UM58, Q8K2V5, Q91YC7
  6. NM_001410281.1NP_001397210.1  peroxisomal targeting signal 1 receptor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124470
    UniProtKB/TrEMBL
    D3Z600
    Related
    ENSMUSP00000108149.2, ENSMUST00000112530.8
  7. NM_008995.3NP_033021.2  peroxisomal targeting signal 1 receptor isoform 1

    See identical proteins and their annotated locations for NP_033021.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Variants 1, 5, 7, and 8 all encode the same isoform (1).
    Source sequence(s)
    AC124470
    Consensus CDS
    CCDS20517.1
    UniProtKB/Swiss-Prot
    O09012, Q3UM58, Q8K2V5, Q91YC7
    Related
    ENSMUSP00000108151.2, ENSMUST00000112532.8
    Conserved Domains (3) summary
    TIGR02917
    Location:348583
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:488516
    TPR; TPR repeat [structural motif]
    cl02686
    Location:307342
    PRY; SPRY-associated domain
  8. NM_175933.3NP_787947.1  peroxisomal targeting signal 1 receptor isoform 2

    See identical proteins and their annotated locations for NP_787947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 2 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AC124470
    Consensus CDS
    CCDS20518.1
    UniProtKB/Swiss-Prot
    O09012
    Related
    ENSMUSP00000079398.6, ENSMUST00000080557.12
    Conserved Domains (2) summary
    sd00006
    Location:451479
    TPR; TPR repeat [structural motif]
    cl26002
    Location:311546
    TPR_11; TPR repeat

RNA

  1. NR_176972.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124470
  2. NR_176973.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124470

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124373774..124392878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)