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Cyb5d2 cytochrome b5 domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 192986, updated on 9-May-2024

Summary

Official Symbol
Cyb5d2provided by MGI
Official Full Name
cytochrome b5 domain containing 2provided by MGI
Primary source
MGI:MGI:2684848
See related
Ensembl:ENSMUSG00000057778 AllianceGenome:MGI:2684848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm2; 9330151E16Rik
Summary
Enables heme binding activity. Acts upstream of or within positive regulation of neuron differentiation. Located in extracellular region. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and skeletal muscle tissue. Orthologous to human CYB5D2 (cytochrome b5 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 4.1), testis adult (RPKM 3.6) and 28 other tissues See more
Orthologs
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Genomic context

See Cyb5d2 in Genome Data Viewer
Location:
11 B4; 11 44.51 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72668058..72686665, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72777232..72795839, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2G 1 Neighboring gene predicted gene, 24143 Neighboring gene STARR-seq mESC enhancer starr_29916 Neighboring gene STARR-positive B cell enhancer ABC_E7012 Neighboring gene ankyrin repeat and FYVE domain containing 1 Neighboring gene predicted gene, 46287 Neighboring gene STARR-positive B cell enhancer ABC_E8424 Neighboring gene zinc finger, ZZ-type with EF hand domain 1 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene Neighboring gene predicted gene, 26121

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
neuferricin
Names
cytochrome b5 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024926.3NP_001020097.2  neuferricin precursor

    See identical proteins and their annotated locations for NP_001020097.2

    Status: VALIDATED

    Source sequence(s)
    AK034043, BC086682, BX632403, CD776759, CJ150252, CJ151047, CJ284318
    Consensus CDS
    CCDS24990.2
    UniProtKB/Swiss-Prot
    A0AUN6, Q0VGS6, Q5SSH8, Q8BHV3
    Related
    ENSMUSP00000078623.6, ENSMUST00000079681.6
    Conserved Domains (1) summary
    pfam00173
    Location:3791
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72668058..72686665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)