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Kcnh6 potassium voltage-gated channel, subfamily H (eag-related), member 6 [ Mus musculus (house mouse) ]

Gene ID: 192775, updated on 5-Mar-2019

Summary

Official Symbol
Kcnh6provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 6provided by MGI
Primary source
MGI:MGI:2684139
See related
Ensembl:ENSMUSG00000001901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
m-erg2
Expression
Broad expression in colon adult (RPKM 1.9), frontal lobe adult (RPKM 1.4) and 17 other tissues See more
Orthologs

Genomic context

See Kcnh6 in Genome Data Viewer
Location:
11; 11 E1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (106007993..106035595)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (105869517..105895378)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Neighboring gene predicted gene, 35971 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2)  1 citation

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC129366

Gene Ontology Provided by MGI

Function Evidence Code Pubs
inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily H member 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037712.2NP_001032801.1  potassium voltage-gated channel subfamily H member 6

    See identical proteins and their annotated locations for NP_001032801.1

    Status: VALIDATED

    Source sequence(s)
    AL596331
    Consensus CDS
    CCDS25545.1
    UniProtKB/TrEMBL
    Q32ME0
    Related
    ENSMUSP00000001965.7, ENSMUST00000001965.13
    Conserved Domains (6) summary
    COG0664
    Location:588701
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29132
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    106007993..106035595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532558.3XP_006532621.1  potassium voltage-gated channel subfamily H member 6 isoform X6

    Conserved Domains (2) summary
    cd00130
    Location:41132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam13426
    Location:29132
    PAS_9; PAS domain
  2. XM_006532554.2XP_006532617.1  potassium voltage-gated channel subfamily H member 6 isoform X5

    UniProtKB/TrEMBL
    M0QW64
    Related
    ENSMUSP00000137675.1, ENSMUST00000145539.1
    Conserved Domains (6) summary
    COG0664
    Location:588701
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29132
    PAS_9; PAS domain
  3. XM_006532552.1XP_006532615.1  potassium voltage-gated channel subfamily H member 6 isoform X3

    Conserved Domains (6) summary
    COG0664
    Location:588701
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29132
    PAS_9; PAS domain
  4. XM_006532553.1XP_006532616.1  potassium voltage-gated channel subfamily H member 6 isoform X4

    Conserved Domains (6) summary
    COG0664
    Location:588701
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29132
    PAS_9; PAS domain
  5. XM_006532550.2XP_006532613.1  potassium voltage-gated channel subfamily H member 6 isoform X1

    Conserved Domains (6) summary
    COG0664
    Location:588701
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29132
    PAS_9; PAS domain
  6. XM_006532551.3XP_006532614.1  potassium voltage-gated channel subfamily H member 6 isoform X2

    Conserved Domains (4) summary
    COG0664
    Location:465578
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:471582
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:173397
    Ion_trans; Ion transport protein
    pfam07885
    Location:340394
    Ion_trans_2; Ion channel

RNA

  1. XR_388374.2 RNA Sequence

  2. XR_388373.2 RNA Sequence

  3. XR_001779926.1 RNA Sequence

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