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Kcnh6 potassium voltage-gated channel, subfamily H (eag-related), member 6 [ Mus musculus (house mouse) ]

Gene ID: 192775, updated on 16-Oct-2021

Summary

Official Symbol
Kcnh6provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 6provided by MGI
Primary source
MGI:MGI:2684139
See related
Ensembl:ENSMUSG00000001901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
m-erg2
Expression
Broad expression in colon adult (RPKM 1.9), frontal lobe adult (RPKM 1.4) and 17 other tissues See more
Orthologs
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Genomic context

See Kcnh6 in Genome Data Viewer
Location:
11; 11 E1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105898871..105926421)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106008044..106035595)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (105869517..105895378)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Neighboring gene predicted gene, 35971 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I, opposite strand Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2)  1 citation

General gene information

Markers

Homology

Clone Names

  • MGC129366

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily H member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037712.2NP_001032801.1  potassium voltage-gated channel subfamily H member 6

    See identical proteins and their annotated locations for NP_001032801.1

    Status: VALIDATED

    Source sequence(s)
    AL596331
    Consensus CDS
    CCDS25545.1
    UniProtKB/TrEMBL
    Q32ME0
    Related
    ENSMUSP00000001965.8, ENSMUST00000001965.14
    Conserved Domains (6) summary
    COG0664
    Location:588701
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29132
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105898871..105926421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532554.4XP_006532617.1  potassium voltage-gated channel subfamily H member 6 isoform X4

    UniProtKB/TrEMBL
    M0QW64
    Related
    ENSMUSP00000137675.2, ENSMUST00000145539.2
    Conserved Domains (2) summary
    PLN03192
    Location:259698
    PLN03192; Voltage-dependent potassium channel; Provisional
    pfam13426
    Location:29132
    PAS_9; PAS domain
  2. XM_006532550.4XP_006532613.1  potassium voltage-gated channel subfamily H member 6 isoform X1

    Conserved Domains (2) summary
    PLN03192
    Location:259698
    PLN03192; Voltage-dependent potassium channel; Provisional
    pfam13426
    Location:29132
    PAS_9; PAS domain
  3. XM_030245696.2XP_030101556.1  potassium voltage-gated channel subfamily H member 6 isoform X2

    Conserved Domains (2) summary
    PLN03192
    Location:259698
    PLN03192; Voltage-dependent potassium channel; Provisional
    pfam13426
    Location:29132
    PAS_9; PAS domain
  4. XM_006532551.5XP_006532614.1  potassium voltage-gated channel subfamily H member 6 isoform X3

    Conserved Domains (1) summary
    PLN03192
    Location:136575
    PLN03192; Voltage-dependent potassium channel; Provisional

RNA

  1. XR_004936864.1 RNA Sequence

  2. XR_004936865.1 RNA Sequence

  3. XR_388374.4 RNA Sequence

  4. XR_004936866.1 RNA Sequence

  5. XR_003949358.2 RNA Sequence

  6. XR_003949357.2 RNA Sequence

  7. XR_004936867.1 RNA Sequence

  8. XR_388373.4 RNA Sequence

  9. XR_004936862.1 RNA Sequence

  10. XR_003949355.1 RNA Sequence

  11. XR_004936860.1 RNA Sequence

  12. XR_004936861.1 RNA Sequence

  13. XR_001779926.3 RNA Sequence

  14. XR_004936863.1 RNA Sequence

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