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Ptpro protein tyrosine phosphatase, receptor type, O [ Mus musculus (house mouse) ]

Gene ID: 19277, updated on 17-Jan-2023

Summary

Official Symbol
Ptproprovided by MGI
Official Full Name
protein tyrosine phosphatase, receptor type, Oprovided by MGI
Primary source
MGI:MGI:1097152
See related
Ensembl:ENSMUSG00000030223 AllianceGenome:MGI:1097152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D28; PTPBK; PTPU2; PTPoc; GLEPP1; PTPROt; PTPphi; Ptpn15; R-PTP-O
Summary
Enables Wnt-protein binding activity; protein homodimerization activity; and protein tyrosine phosphatase activity. Involved in several processes, including peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; plasma membrane bounded cell projection organization; and slit diaphragm assembly. Located in several cellular components, including apical plasma membrane; glutamatergic synapse; and lateral plasma membrane. Is active in GABA-ergic synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 15.3), CNS E18 (RPKM 13.3) and 9 other tissues See more
Orthologs
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Genomic context

See Ptpro in Genome Data Viewer
Location:
6; 6 G1
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (137229189..137441632)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (137252299..137464634)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RAS-like, estrogen-regulated, growth-inhibitor Neighboring gene predicted gene, 52923 Neighboring gene predicted gene, 38914 Neighboring gene predicted gene, 52924 Neighboring gene epidermal growth factor receptor pathway substrate 8 Neighboring gene predicted gene, 38915

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Wnt-protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in glomerulus development ISO
Inferred from Sequence Orthology
more info
 
involved_in lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in podocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in podocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glomerular filtration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of glomerular filtration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in slit diaphragm assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase O
Names
PTPase U2
glomerular epithelial protein 1
protein tyrosine phosphatase U2
protein tyrosine phosphatase, non-receptor type 15
receptor protein tyrosine phosphatase RO
NP_001157873.1
NP_001157874.1
NP_001157875.1
NP_035346.3
XP_036021846.1
XP_036021847.1
XP_036021848.1
XP_036021849.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164401.2NP_001157873.1  receptor-type tyrosine-protein phosphatase O isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC093120, AC144767, AC163627
    Consensus CDS
    CCDS51943.1
    UniProtKB/TrEMBL
    E9Q4I1
    Related
    ENSMUSP00000127112.2, ENSMUST00000167679.8
    Conserved Domains (4) summary
    smart00194
    Location:9191174
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9471175
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:444536
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:735815
    fn3; Fibronectin type III domain
  2. NM_001164402.2NP_001157874.1  receptor-type tyrosine-protein phosphatase O isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC093120, AC163627
    Consensus CDS
    CCDS51944.1
    UniProtKB/TrEMBL
    E9PVJ6
    Related
    ENSMUSP00000131764.2, ENSMUST00000167002.4
    Conserved Domains (2) summary
    smart00194
    Location:126381
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:154382
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_001164403.2NP_001157875.1  receptor-type tyrosine-protein phosphatase O isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC093120, AC163627
    Consensus CDS
    CCDS85176.1
    UniProtKB/TrEMBL
    A0A0N4SUY2
    Related
    ENSMUSP00000144870.2, ENSMUST00000203914.2
    Conserved Domains (2) summary
    smart00194
    Location:98353
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:126354
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. NM_001410275.1NP_001397204.1  receptor-type tyrosine-protein phosphatase O isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093120, AC163627
    UniProtKB/TrEMBL
    Q3UWY6
  5. NM_011216.4NP_035346.3  receptor-type tyrosine-protein phosphatase O isoform 1 precursor

    See identical proteins and their annotated locations for NP_035346.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC093120, AC144767, AC163627
    Consensus CDS
    CCDS20664.1
    UniProtKB/Swiss-Prot
    E9Q612, Q7TSY7
    Related
    ENSMUSP00000076364.7, ENSMUST00000077115.13
    Conserved Domains (4) summary
    smart00194
    Location:9471202
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9751203
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:444536
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:735815
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    137229189..137441632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165953.1XP_036021846.1  receptor-type tyrosine-protein phosphatase O isoform X1

    Conserved Domains (3) summary
    cd00063
    Location:479571
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14614
    Location:9961240
    R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O
    pfam00041
    Location:770850
    fn3; Fibronectin type III domain
  2. XM_036165954.1XP_036021847.1  receptor-type tyrosine-protein phosphatase O isoform X2

    Conserved Domains (3) summary
    cd00063
    Location:479571
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14614
    Location:9681212
    R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O
    pfam00041
    Location:770850
    fn3; Fibronectin type III domain
  3. XM_036165956.1XP_036021849.1  receptor-type tyrosine-protein phosphatase O isoform X4

    Conserved Domains (3) summary
    cd00063
    Location:279371
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14614
    Location:7961040
    R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O
    pfam00041
    Location:570650
    fn3; Fibronectin type III domain
  4. XM_036165955.1XP_036021848.1  receptor-type tyrosine-protein phosphatase O isoform X3

    Conserved Domains (3) summary
    cd00063
    Location:443535
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14614
    Location:9601204
    R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O
    pfam00041
    Location:734814
    fn3; Fibronectin type III domain