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Ptpro protein tyrosine phosphatase, receptor type, O [ Mus musculus (house mouse) ]

Gene ID: 19277, updated on 12-Aug-2019

Summary

Official Symbol
Ptproprovided by MGI
Official Full Name
protein tyrosine phosphatase, receptor type, Oprovided by MGI
Primary source
MGI:MGI:1097152
See related
Ensembl:ENSMUSG00000030223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D28; PTPBK; PTPU2; PTPoc; GLEPP1; PTPROt; PTPphi; Ptpn15; R-PTP-O
Expression
Biased expression in frontal lobe adult (RPKM 15.3), CNS E18 (RPKM 13.3) and 9 other tissues See more
Orthologs

Genomic context

See Ptpro in Genome Data Viewer
Location:
6; 6 G1
Exon count:
29
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (137252299..137464634)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (137200820..137413155)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115490440 Neighboring gene RAS-like, estrogen-regulated, growth-inhibitor Neighboring gene predicted gene, 38914 Neighboring gene uncharacterized LOC115490441 Neighboring gene epidermal growth factor receptor pathway substrate 8 Neighboring gene predicted gene, 38915

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Wnt-protein binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
glomerular visceral epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glomerulus development ISO
Inferred from Sequence Orthology
more info
 
lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of glomerular filtration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synapse organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
slit diaphragm assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase O
Names
PTPase U2
glomerular epithelial protein 1
protein tyrosine phosphatase U2
protein tyrosine phosphatase, non-receptor type 15
receptor protein tyrosine phosphatase RO
NP_001157873.1
NP_001157874.1
NP_001157875.1
NP_035346.3
XP_030111098.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164401.1NP_001157873.1  receptor-type tyrosine-protein phosphatase O isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC093120, AC144767, AC163627, AW490226
    Consensus CDS
    CCDS51943.1
    UniProtKB/TrEMBL
    E9Q4I1
    Related
    ENSMUSP00000127112.1, ENSMUST00000167679.7
    Conserved Domains (4) summary
    smart00194
    Location:9191174
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9471175
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:444536
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:735815
    fn3; Fibronectin type III domain
  2. NM_001164402.1NP_001157874.1  receptor-type tyrosine-protein phosphatase O isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC093120, AC163627, AW490226
    Consensus CDS
    CCDS51944.1
    UniProtKB/TrEMBL
    E9PVJ6
    Related
    ENSMUSP00000131764.1, ENSMUST00000167002.3
    Conserved Domains (2) summary
    smart00194
    Location:126381
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:154382
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_001164403.1NP_001157875.1  receptor-type tyrosine-protein phosphatase O isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC093120, AC163627, AW490226
    Consensus CDS
    CCDS85176.1
    UniProtKB/TrEMBL
    A0A0N4SUY2
    Related
    ENSMUSP00000144870.1, ENSMUST00000203914.1
    Conserved Domains (2) summary
    smart00194
    Location:98353
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:126354
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. NM_011216.3NP_035346.3  receptor-type tyrosine-protein phosphatase O isoform 1 precursor

    See identical proteins and their annotated locations for NP_035346.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC093120, AC163627, AW490226, BC052743, CB523320
    Consensus CDS
    CCDS20664.1
    UniProtKB/Swiss-Prot
    E9Q612
    Related
    ENSMUSP00000076364.6, ENSMUST00000077115.12
    Conserved Domains (4) summary
    smart00194
    Location:9471202
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9751203
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:444536
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:735815
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

    Range
    137252299..137464634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255238.1XP_030111098.1  receptor-type tyrosine-protein phosphatase O isoform X1

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