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Ptprn2 protein tyrosine phosphatase receptor type N polypeptide 2 [ Mus musculus (house mouse) ]

Gene ID: 19276, updated on 9-May-2024

Summary

Official Symbol
Ptprn2provided by MGI
Official Full Name
protein tyrosine phosphatase receptor type N polypeptide 2provided by MGI
Primary source
MGI:MGI:107418
See related
Ensembl:ENSMUSG00000056553 AllianceGenome:MGI:107418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phol; PTP-NP; IA2beta; phogrin; mKIAA0387; 4930425H11Rik
Summary
Predicted to enable protein tyrosine phosphatase activity. Involved in insulin secretion involved in cellular response to glucose stimulus and neurotransmitter secretion. Located in secretory granule membrane and synaptic vesicle membrane. Is expressed in several structures, including foregut-midgut junction; midgut endoderm; and nervous system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine phosphatase receptor type N2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 41.7), frontal lobe adult (RPKM 37.3) and 11 other tissues See more
Orthologs
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Genomic context

See Ptprn2 in Genome Data Viewer
Location:
12 F2; 12 62.65 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (116449316..117241787)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (116485695..117278167)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33405 Neighboring gene U7 small nuclear RNA, pseudogene 1 Neighboring gene predicted gene, 25112 Neighboring gene predicted gene 6750 Neighboring gene STARR-positive B cell enhancer mm9_chr12:117858552-117858853 Neighboring gene STARR-seq mESC enhancer starr_33408 Neighboring gene ATPase inhibitory factor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33409 Neighboring gene predicted gene, 31336 Neighboring gene STARR-seq mESC enhancer starr_33412 Neighboring gene STARR-seq mESC enhancer starr_33413 Neighboring gene predicted gene 10421 Neighboring gene predicted gene, 53773 Neighboring gene STARR-seq mESC enhancer starr_33420 Neighboring gene predicted gene 5441 Neighboring gene microRNA 153 Neighboring gene STARR-positive B cell enhancer mm9_chr12:118623787-118624087 Neighboring gene predicted gene, 39559 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:118685906-118686089 Neighboring gene predicted gene, 31482

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0387

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin secretion involved in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase N2
Names
IA-2 beta
PTP IA-2beta
R-PTP-N2
protein tyrosine phosphatase-NP
NP_035345.2
XP_011242321.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011215.2NP_035345.2  receptor-type tyrosine-protein phosphatase N2 precursor

    See identical proteins and their annotated locations for NP_035345.2

    Status: VALIDATED

    Source sequence(s)
    AC160634, AC164641, AK138655, BC133678
    Consensus CDS
    CCDS36576.1
    UniProtKB/Swiss-Prot
    O09134, P70328, P80560, Q1RLJ1
    UniProtKB/TrEMBL
    A3KN68
    Related
    ENSMUSP00000064046.8, ENSMUST00000070733.9
    Conserved Domains (4) summary
    smart00194
    Location:731990
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:758990
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam11548
    Location:498583
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:72126
    RESP18; RESP18 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    116449316..117241787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244019.4XP_011242321.1  receptor-type tyrosine-protein phosphatase N2 isoform X1

    UniProtKB/TrEMBL
    A3KN68
    Conserved Domains (2) summary
    cd14610
    Location:675957
    R-PTP-N2; PTP-like domain of receptor-type tyrosine-protein phosphatase N2
    pfam11548
    Location:457545
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2