Ptprj protein tyrosine phosphatase receptor type J [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptprjprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Jprovided by MGI
Primary source: MGI:MGI:104574
See related: Ensembl:ENSMUSG00000025314 AllianceGenome:MGI:104574
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BET; Byp; Scc1; CD148; DEP-1; Ptpb2; RPTPJ; Scc-1; R-PTP-J; PTPbeta2; R-PTP-eta
Summary: Enables protein tyrosine phosphatase activity. Involved in several processes, including regulation of cell migration; regulation of protein phosphorylation; and regulation of signal transduction. Acts upstream of or within heart development; oligodendrocyte differentiation; and vasculogenesis. Located in immunological synapse and ruffle membrane. Is expressed in midbrain; renal calyx; renal pelvis; and superior colliculus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 9.5), cortex adult (RPKM 8.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E1; 2 50.19 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (90260100..90411102, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (90429756..90580694, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High-fat diet alters N-glycosylation of PTPRJ in murine liver.
Title: High-fat diet alters N-glycosylation of PTPRJ in murine liver.
The protein tyrosine phosphatase PTPRJ/DEP-1 contributes to the regulation of the Notch-signaling pathway and sprouting angiogenesis.
Title: The protein tyrosine phosphatase PTPRJ/DEP-1 contributes to the regulation of the Notch-signaling pathway and sprouting angiogenesis.
CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.
Title: CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.
PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl-mediated ubiquitination of NFATc1 in late osteoclastogenesis.
Title: PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl-mediated ubiquitination of NFATc1 in late osteoclastogenesis.
Study shows that protein tyrosine phosphatase receptor type J (PTPRJ) regulates retinal axonal projections by inhibiting eph and abl kinases in mice.
Title: Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Regulates Retinal Axonal Projections by Inhibiting Eph and Abl Kinases in Mice.
Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia.
Title: Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia.
Ptprj-KO mice exhibit improved glucose and insulin tolerance through enhanced insulin signaling. We herein demonstrated that Ptprj-KO mice exhibited lean phenotypes with lower adiposity because of reduced food intake through enhanced leptin signaling.
Title: PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance.
This study establishes Csk and CD148 as critical molecular switches controlling the thrombotic and hemostatic capacity of platelets and reveals cell-intrinsic mechanisms that prevent pathological thrombosis from occurring.
Title: Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.
This study demonstrated that the protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.
Title: The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.
our results established DEP-1 as an essential driver of VEGF-dependent permeability, angiogenesis, and metastasis
Title: Tyrosine Phosphatase PTPRJ/DEP-1 Is an Essential Promoter of Vascular Permeability, Angiogenesis, and Tumor Progression.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)
QTL (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC151692P1 (e-PCR)
- UniSTS:271164

D2Mit272 (e-PCR), detects polymorphism
- UniSTS:129155

AW555355 (e-PCR)
- UniSTS:185482

D3Wox33 (e-PCR)
- UniSTS:240530

Ptprj (e-PCR), detects polymorphism
- UniSTS:536489

D45212 (e-PCR)
- UniSTS:163290

AI450271 (e-PCR)
- UniSTS:178651

BB238754 (e-PCR)
- UniSTS:207350

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables delta-catenin binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase eta

Names: HPTP beta-like tyrosine phosphatase; colon tumor susceptibility 1; protein-tyrosine phosphatase eta; susceptibility to colon cancer 1

NP_001129129.1

EC 3.1.3.48

NP_033008.4

EC 3.1.3.48

XP_006499054.1

EC 3.1.3.48

XP_006499055.1

EC 3.1.3.48

XP_006499056.1

EC 3.1.3.48

XP_006499057.1

EC 3.1.3.48

XP_036015593.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135657.1 → NP_001129129.1 receptor-type tyrosine-protein phosphatase eta isoform 2

Status: VALIDATED

Source sequence(s)

AL954341

Consensus CDS

CCDS50629.1

UniProtKB/TrEMBL

A2AWF9, E9Q4S7

Related

ENSMUSP00000107121.3, ENSMUST00000111495.9

Conserved Domains (5) summary

smart00060
Location:461 → 528

FN3; Fibronectin type 3 domain

smart00194
Location:960 → 1217

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:987 → 1217

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:375 → 459

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:69 → 129

fn3; Fibronectin type III domain
NM_008982.6 → NP_033008.4 receptor-type tyrosine-protein phosphatase eta isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL935132, AL954341

Consensus CDS

CCDS50630.1

UniProtKB/Swiss-Prot

Q3UH64, Q3UHL5, Q541R5, Q64455, Q8CIW9, Q8K3Q2

UniProtKB/TrEMBL

E9Q4S7

Related

ENSMUSP00000129592.5, ENSMUST00000168621.5

Conserved Domains (5) summary

smart00060
Location:442 → 509

FN3; Fibronectin type 3 domain

cd00063
Location:356 → 440

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14615
Location:970 → 1198

R-PTPc-J; catalytic domain of receptor-type tyrosine-protein phosphatase J

pfam00041
Location:50 → 110

fn3; Fibronectin type III domain

pfam18861
Location:718 → 901

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

90260100..90411102 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498991.5 → XP_006499054.1 receptor-type tyrosine-protein phosphatase eta isoform X1

UniProtKB/TrEMBL

E9Q4S7

Conserved Domains (5) summary

smart00060
Location:555 → 622

FN3; Fibronectin type 3 domain

cd00063
Location:469 → 553

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14615
Location:1083 → 1311

R-PTPc-J; catalytic domain of receptor-type tyrosine-protein phosphatase J

pfam00041
Location:162 → 222

fn3; Fibronectin type III domain

pfam18861
Location:831 → 1014

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
XM_036159700.1 → XP_036015593.1 receptor-type tyrosine-protein phosphatase eta isoform X4

UniProtKB/TrEMBL

E9Q4S7

Conserved Domains (6) summary

smart00060
Location:369 → 436

FN3; Fibronectin type 3 domain

cd00063
Location:283 → 367

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14615
Location:897 → 1125

R-PTPc-J; catalytic domain of receptor-type tyrosine-protein phosphatase J

pfam00041
Location:197 → 274

fn3; Fibronectin type III domain

pfam18861
Location:663 → 828

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cl21522
Location:10 → 36

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006498994.4 → XP_006499057.1 receptor-type tyrosine-protein phosphatase eta isoform X5

UniProtKB/TrEMBL

A2AWF8, E9Q4S7

Conserved Domains (6) summary

smart00060
Location:368 → 435

FN3; Fibronectin type 3 domain

cd00063
Location:282 → 366

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14615
Location:896 → 1124

R-PTPc-J; catalytic domain of receptor-type tyrosine-protein phosphatase J

pfam00041
Location:196 → 273

fn3; Fibronectin type III domain

pfam18861
Location:644 → 827

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cl21522
Location:10 → 36

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006498993.4 → XP_006499056.1 receptor-type tyrosine-protein phosphatase eta isoform X3

UniProtKB/TrEMBL

E9Q4S7

Conserved Domains (5) summary

smart00060
Location:461 → 528

FN3; Fibronectin type 3 domain

cd00063
Location:375 → 459

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14615
Location:989 → 1217

R-PTPc-J; catalytic domain of receptor-type tyrosine-protein phosphatase J

pfam00041
Location:69 → 129

fn3; Fibronectin type III domain

pfam18861
Location:737 → 920

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
XM_006498992.4 → XP_006499055.1 receptor-type tyrosine-protein phosphatase eta isoform X2

UniProtKB/TrEMBL

E9Q4S7

Conserved Domains (5) summary

smart00060
Location:462 → 529

FN3; Fibronectin type 3 domain

cd00063
Location:376 → 460

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14615
Location:990 → 1218

R-PTPc-J; catalytic domain of receptor-type tyrosine-protein phosphatase J

pfam00041
Location:69 → 129

fn3; Fibronectin type III domain

pfam18861
Location:738 → 921

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J