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AGO4 argonaute RISC component 4 [ Homo sapiens (human) ]

Gene ID: 192670, updated on 13-Mar-2020

Summary

Official Symbol
AGO4provided by HGNC
Official Full Name
argonaute RISC component 4provided by HGNC
Primary source
HGNC:HGNC:18424
See related
Ensembl:ENSG00000134698 MIM:607356
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF2C4
Summary
This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in skin (RPKM 10.1), bone marrow (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See AGO4 in Genome Data Viewer
Location:
1p34.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (35807630..35857890)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36273231..36323491)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7840 Neighboring gene chromosome 1 open reading frame 216 Neighboring gene claspin Neighboring gene argonaute RISC component 1 Neighboring gene argonaute RISC catalytic component 3 Neighboring gene uncharacterized LOC105378647

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA secondary structure unwinding IDA
Inferred from Direct Assay
more info
PubMed 
RNA secondary structure unwinding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
NOT mRNA cleavage involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
NOT mRNA cleavage involved in gene silencing by siRNA IDA
Inferred from Direct Assay
more info
PubMed 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
male meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
miRNA loading onto RISC involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
miRNA mediated inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
miRNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression TAS
Traceable Author Statement
more info
 
positive regulation of gene expression TAS
Traceable Author Statement
more info
 
posttranscriptional gene silencing by RNA TAS
Traceable Author Statement
more info
 
pre-miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
production of miRNAs involved in gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
synaptonemal complex assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P-body IEA
Inferred from Electronic Annotation
more info
 
RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
RISC-loading complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein argonaute-4
Names
argonaute 4, RISC catalytic component
argonaute RISC catalytic component 4
eukaryotic translation initiation factor 2C, 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017629.4NP_060099.2  protein argonaute-4

    See identical proteins and their annotated locations for NP_060099.2

    Status: REVIEWED

    Source sequence(s)
    AB046787, AL354864, AL359186, CA419947
    Consensus CDS
    CCDS397.1
    UniProtKB/Swiss-Prot
    Q9HCK5
    Related
    ENSP00000362306.3, ENST00000373210.4
    Conserved Domains (4) summary
    cd02846
    Location:217337
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:384819
    Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
    pfam08699
    Location:166216
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:26155
    ArgoN; N-terminal domain of argonaute

RNA

  1. NR_146062.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at both the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because translation of the expected ORF would render the transcript a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AL354864, AL359186

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    35807630..35857890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270578.3XP_005270635.1  protein argonaute-4 isoform X1

    See identical proteins and their annotated locations for XP_005270635.1

    Conserved Domains (4) summary
    cd02846
    Location:150270
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:317752
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:101149
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:488
    ArgoN; N-terminal domain of argonaute
  2. XM_005270579.3XP_005270636.1  protein argonaute-4 isoform X1

    See identical proteins and their annotated locations for XP_005270636.1

    Conserved Domains (4) summary
    cd02846
    Location:150270
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:317752
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:101149
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:488
    ArgoN; N-terminal domain of argonaute
  3. XM_024453795.1XP_024309563.1  protein argonaute-4 isoform X4

    Conserved Domains (2) summary
    cd02846
    Location:193
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:140575
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
  4. XM_011540883.2XP_011539185.1  protein argonaute-4 isoform X2

    Conserved Domains (3) summary
    cd02846
    Location:67187
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:234669
    Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
    pfam08699
    Location:1766
    ArgoL1; Argonaute linker 1 domain
  5. XM_011540884.2XP_011539186.1  protein argonaute-4 isoform X3

    Conserved Domains (2) summary
    cd02846
    Location:16136
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:183618
    Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...

RNA

  1. XR_246244.3 RNA Sequence

  2. XR_001737019.1 RNA Sequence

  3. XR_246243.3 RNA Sequence

  4. XR_001737021.1 RNA Sequence

  5. XR_001737022.1 RNA Sequence

  6. XR_946567.2 RNA Sequence

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