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Ptpre protein tyrosine phosphatase, receptor type, E [ Mus musculus (house mouse) ]

Gene ID: 19267, updated on 8-Dec-2022

Summary

Official Symbol
Ptpreprovided by MGI
Official Full Name
protein tyrosine phosphatase, receptor type, Eprovided by MGI
Primary source
MGI:MGI:97813
See related
Ensembl:ENSMUSG00000041836 AllianceGenome:MGI:97813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTPe; PTPepsilon; RPTPepsilon
Summary
Enables identical protein binding activity and protein tyrosine phosphatase activity. Involved in negative regulation of insulin receptor signaling pathway and regulation of mast cell activation. Acts upstream of or within transmembrane receptor protein tyrosine phosphatase signaling pathway. Located in cytoplasm and plasma membrane. Is expressed in midbrain and superior colliculus. Orthologous to human PTPRE (protein tyrosine phosphatase receptor type E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 7.9), thymus adult (RPKM 6.2) and 27 other tissues See more
Orthologs
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Genomic context

See Ptpre in Genome Data Viewer
Location:
7 F3; 7 81.27 cM
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (135139195..135288023)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (135537824..135686294)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36356 Neighboring gene clarin 3 Neighboring gene microRNA 1962 Neighboring gene RIKEN cDNA 5830432E09 gene Neighboring gene antigen identified by monoclonal antibody Ki 67 Neighboring gene predicted gene, 36431

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase epsilon
Names
R-PTP-epsilon
protein-tyrosine phosphatase epsilon
NP_001303607.1
NP_001303608.1
NP_001303609.1
NP_001303610.1
NP_035342.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316678.1NP_001303607.1  receptor-type tyrosine-protein phosphatase epsilon isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC123047, AK004602, AK132455, U40280
    Consensus CDS
    CCDS85444.1
    UniProtKB/Swiss-Prot
    P49446
    UniProtKB/TrEMBL
    A0A1B0GRT6, Q3V1H5
    Related
    ENSMUSP00000147656.2, ENSMUST00000209256.2
    Conserved Domains (2) summary
    smart00194
    Location:154412
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:180412
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001316679.1NP_001303608.1  receptor-type tyrosine-protein phosphatase epsilon isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC123047, U40280
    Consensus CDS
    CCDS21944.1
    UniProtKB/Swiss-Prot
    P49446, Q64496
    Related
    ENSMUSP00000147313.2, ENSMUST00000210833.2
    Conserved Domains (2) summary
    smart00194
    Location:134392
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:160392
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_001316680.1NP_001303609.1  receptor-type tyrosine-protein phosphatase epsilon isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains two alternate exons in place of the first exon compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC123047, AC151841, BC053408, U40280
    Consensus CDS
    CCDS85445.1
    UniProtKB/Swiss-Prot
    P49446
    UniProtKB/TrEMBL
    A0A1B0GRH2
    Related
    ENSMUSP00000147524.2, ENSMUST00000211788.2
    Conserved Domains (2) summary
    smart00194
    Location:147405
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:173405
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. NM_001316681.1NP_001303610.1  receptor-type tyrosine-protein phosphatase epsilon isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in place of the first exon compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC123047, AK132455, BY210317, U40280
    Consensus CDS
    CCDS85446.1
    UniProtKB/Swiss-Prot
    P49446
    UniProtKB/TrEMBL
    Q3V1H5
    Related
    ENSMUSP00000147613.2, ENSMUST00000209979.2
    Conserved Domains (2) summary
    smart00194
    Location:77335
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:103335
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. NM_011212.3NP_035342.3  receptor-type tyrosine-protein phosphatase epsilon isoform b precursor

    See identical proteins and their annotated locations for NP_035342.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC123047, AC151838, AC151841
    Consensus CDS
    CCDS21944.1
    UniProtKB/Swiss-Prot
    P49446, Q64496
    Related
    ENSMUSP00000073616.7, ENSMUST00000073961.8
    Conserved Domains (2) summary
    smart00194
    Location:134392
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:160392
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    135139195..135288023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001785494.3 RNA Sequence