Format

Send to:

Choose Destination

AGO3 argonaute RISC catalytic component 3 [ Homo sapiens (human) ]

Gene ID: 192669, updated on 25-Jan-2022

Summary

Official Symbol
AGO3provided by HGNC
Official Full Name
argonaute RISC catalytic component 3provided by HGNC
Primary source
HGNC:HGNC:18421
See related
Ensembl:ENSG00000126070 MIM:607355; AllianceGenome:HGNC:18421
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF2C3
Summary
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 1.4), testis (RPKM 1.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See AGO3 in Genome Data Viewer
Location:
1p34.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (35925683..36072500)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36396706..36538101)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10959 Neighboring gene claspin Neighboring gene argonaute RISC component 4 Neighboring gene argonaute RISC component 1 Neighboring gene uncharacterized LOC105378647 Neighboring gene magnesium transporter 1 pseudogene Neighboring gene tektin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of eukaryotic translation initiation factor 2C, 3 (EIF2C3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12765, MGC86946

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables endoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables endoribonuclease activity, cleaving miRNA-paired mRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
 
part_of RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RISC-loading complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed nuclear chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein argonaute-3
Names
argonaute 3, RISC catalytic component
eukaryotic translation initiation factor 2C, 3
hAgo3
NP_079128.2
NP_803171.1
XP_005270632.1
XP_005270633.1
XP_011539181.1
XP_011539184.1
XP_016856012.1
XP_016856013.1
XP_016856014.1
XP_016856015.1
XP_016856016.1
XP_016856017.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024852.4NP_079128.2  protein argonaute-3 isoform a

    See identical proteins and their annotated locations for NP_079128.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a).
    Source sequence(s)
    AA251146, AK303929, AL138787, AL139286, BF979526, BX104163
    Consensus CDS
    CCDS399.1
    UniProtKB/Swiss-Prot
    Q9H9G7
    UniProtKB/TrEMBL
    B4E1P5
    Related
    ENSP00000362287.3, ENST00000373191.9
    Conserved Domains (4) summary
    cd02846
    Location:228348
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:393818
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:177227
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:73167
    ArgoN; N-terminal domain of argonaute
  2. NM_177422.3NP_803171.1  protein argonaute-3 isoform b

    See identical proteins and their annotated locations for NP_803171.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, which causes translation initiation at a downstream start codon, compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AA251146, AL138787, BC025769, BF979526, BX104163
    Consensus CDS
    CCDS400.1
    UniProtKB/Swiss-Prot
    Q9H9G7
    Related
    ENSP00000246314.6, ENST00000246314.10
    Conserved Domains (2) summary
    cd02846
    Location:1114
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:159584
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    35925683..36072500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000523.2XP_016856012.1  protein argonaute-3 isoform X1

    UniProtKB/Swiss-Prot
    Q9H9G7
    Conserved Domains (4) summary
    cd02846
    Location:228348
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:393818
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:177227
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:73167
    ArgoN; N-terminal domain of argonaute
  2. XM_005270575.4XP_005270632.1  protein argonaute-3 isoform X1

    See identical proteins and their annotated locations for XP_005270632.1

    UniProtKB/Swiss-Prot
    Q9H9G7
    Conserved Domains (4) summary
    cd02846
    Location:228348
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:393818
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:177227
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:73167
    ArgoN; N-terminal domain of argonaute
  3. XM_011540879.3XP_011539181.1  protein argonaute-3 isoform X2

    See identical proteins and their annotated locations for XP_011539181.1

    Conserved Domains (4) summary
    cd02846
    Location:213333
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:378803
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    pfam08699
    Location:162212
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:58152
    ArgoN; N-terminal domain of argonaute
  4. XM_017000528.2XP_016856017.1  protein argonaute-3 isoform X4

    Conserved Domains (2) summary
    cd02846
    Location:173
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:118543
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
  5. XM_017000526.2XP_016856015.1  protein argonaute-3 isoform X3

    UniProtKB/Swiss-Prot
    Q9H9G7
    Conserved Domains (2) summary
    cd02846
    Location:1114
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:159584
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
  6. XM_017000525.2XP_016856014.1  protein argonaute-3 isoform X3

    UniProtKB/Swiss-Prot
    Q9H9G7
    Conserved Domains (2) summary
    cd02846
    Location:1114
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:159584
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
  7. XM_011540882.3XP_011539184.1  protein argonaute-3 isoform X3

    See identical proteins and their annotated locations for XP_011539184.1

    UniProtKB/Swiss-Prot
    Q9H9G7
    Conserved Domains (2) summary
    cd02846
    Location:1114
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:159584
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
  8. XM_017000524.2XP_016856013.1  protein argonaute-3 isoform X3

    UniProtKB/Swiss-Prot
    Q9H9G7
    Conserved Domains (2) summary
    cd02846
    Location:1114
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:159584
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
  9. XM_017000527.2XP_016856016.1  protein argonaute-3 isoform X3

    UniProtKB/Swiss-Prot
    Q9H9G7
    Conserved Domains (2) summary
    cd02846
    Location:1114
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:159584
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
  10. XM_005270576.4XP_005270633.1  protein argonaute-3 isoform X4

    Conserved Domains (2) summary
    cd02846
    Location:173
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:118543
    Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
Support Center