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KRT24 keratin 24 [ Homo sapiens (human) ]

Gene ID: 192666, updated on 26-Nov-2021

Summary

Official Symbol
KRT24provided by HGNC
Official Full Name
keratin 24provided by HGNC
Primary source
HGNC:HGNC:18527
See related
Ensembl:ENSG00000167916 MIM:607742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K24; KA24
Summary
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jun 2009]
Expression
Biased expression in esophagus (RPKM 10.1), colon (RPKM 5.1) and 2 other tissues See more
Orthologs
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Genomic context

See KRT24 in Genome Data Viewer
Location:
17q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (40694246..40703752, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38854243..38860004, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 Neighboring gene keratin 222 Neighboring gene uncharacterized LOC105371775 Neighboring gene keratin 223, pseudogene Neighboring gene keratin 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-02-02)

ClinGen Genome Curation Page
Haploinsufficency

Dosage sensitivity unlikely (Last evaluated 2021-02-02)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20261, MGC138169, MGC138173

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cytoskeletal 24
Names
CK-24
cytokeratin-24
keratin 24, type I
type I keratin-24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012417.1 RefSeqGene

    Range
    4999..10760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_019016.3NP_061889.2  keratin, type I cytoskeletal 24

    See identical proteins and their annotated locations for NP_061889.2

    Status: REVIEWED

    Source sequence(s)
    AC090283, AK000268, BC111968
    Consensus CDS
    CCDS11372.1
    UniProtKB/Swiss-Prot
    Q2M2I5
    Related
    ENSP00000264651.2, ENST00000264651.3
    Conserved Domains (1) summary
    pfam00038
    Location:140452
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    40694246..40703752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024299.1XP_016879788.1  keratin, type I cytoskeletal 24 isoform X1

  2. XM_011524460.2XP_011522762.1  keratin, type I cytoskeletal 24 isoform X3

    Conserved Domains (1) summary
    pfam00038
    Location:52349
    Filament; Intermediate filament protein
  3. XM_006721739.3XP_006721802.1  keratin, type I cytoskeletal 24 isoform X2

    Conserved Domains (1) summary
    pfam00038
    Location:58354
    Filament; Intermediate filament protein
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