U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arhgdia Rho GDP dissociation inhibitor alpha [ Mus musculus (house mouse) ]

Gene ID: 192662, updated on 14-May-2024

Summary

Official Symbol
Arhgdiaprovided by MGI
Official Full Name
Rho GDP dissociation inhibitor alphaprovided by MGI
Primary source
MGI:MGI:2178103
See related
Ensembl:ENSMUSG00000025132 AllianceGenome:MGI:2178103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gdi-1; RhoDGI; Rho-GDI; RhoGDI-1; rho GDI 1; 5330430M07Rik; Rho GDI alpha; rho-GDI alpha
Summary
Enables Rho GDP-dissociation inhibitor activity. Involved in semaphorin-plexin signaling pathway. Acts upstream of or within Rho protein signal transduction and regulation of protein localization. Located in immunological synapse and nucleus. Is expressed in brain and heart. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 291.0), lung adult (RPKM 246.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Arhgdia in Genome Data Viewer
Location:
11 E2; 11 84.29 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120468925..120472450, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120578099..120581624, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 27 Neighboring gene prolyl 4-hydroxylase, beta polypeptide Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120434472-120434581 Neighboring gene predicted gene 3807 Neighboring gene STARR-positive B cell enhancer ABC_E1854 Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC7904, MGC101921

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Rho GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Rho GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho GDP-dissociation inhibitor 1
Names
Rho GDIalpha
Rho GDP dissociation inhibitor (GDI) alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363425.1NP_001350354.1  rho GDP-dissociation inhibitor 1

    Status: VALIDATED

    Source sequence(s)
    AK077343, AL663030
    Consensus CDS
    CCDS25743.1
    UniProtKB/Swiss-Prot
    Q5M9P6, Q8BPI0, Q99KC4, Q99PT1
    Related
    ENSMUSP00000063714.6, ENSMUST00000067936.6
    Conserved Domains (1) summary
    pfam02115
    Location:11201
    Rho_GDI; RHO protein GDP dissociation inhibitor
  2. NM_133796.8NP_598557.3  rho GDP-dissociation inhibitor 1

    See identical proteins and their annotated locations for NP_598557.3

    Status: VALIDATED

    Source sequence(s)
    AK165241, AL663030, CJ091996
    Consensus CDS
    CCDS25743.1
    UniProtKB/Swiss-Prot
    Q5M9P6, Q8BPI0, Q99KC4, Q99PT1
    Related
    ENSMUSP00000101803.4, ENSMUST00000106197.10
    Conserved Domains (1) summary
    pfam02115
    Location:11201
    Rho_GDI; RHO protein GDP dissociation inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120468925..120472450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)