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Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 192656, updated on 10-Jun-2024

Summary

Official Symbol
Ripk2provided by MGI
Official Full Name
receptor (TNFRSF)-interacting serine-threonine kinase 2provided by MGI
Primary source
MGI:MGI:1891456
See related
Ensembl:ENSMUSG00000041135 AllianceGenome:MGI:1891456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCK; RICK; RIP2; CARD3; CARDIAK; D4Bwg0615e; 2210420D18Rik
Summary
This gene encodes a member of the receptor-interacting protein family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain, and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of nuclear factor kappa B and inducer of apoptosis in response to various stimuli. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in ovary adult (RPKM 9.1), adrenal adult (RPKM 8.0) and 28 other tissues See more
Orthologs
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Genomic context

See Ripk2 in Genome Data Viewer
Location:
4 A2; 4 6.7 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (16122740..16163674, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (16122732..16163678, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6155 Neighboring gene nibrin Neighboring gene oxidative stress induced growth inhibitor family member 2 Neighboring gene RIKEN cDNA gene A530072M11 Neighboring gene STARR-positive B cell enhancer ABC_E1638 Neighboring gene STARR-positive B cell enhancer ABC_E1028 Neighboring gene STARR-seq mESC enhancer starr_09657 Neighboring gene STARR-seq mESC enhancer starr_09658 Neighboring gene mortality factor 4 like 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09660 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables CARD domain binding ISO
Inferred from Sequence Orthology
more info
 
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables LIM domain binding ISO
Inferred from Sequence Orthology
more info
 
enables caspase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to lipoteichoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to peptidoglycan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 1 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T-helper 1 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of xenophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
NOT acts_upstream_of_or_within regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to interleukin-12 IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to interleukin-18 IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of xenophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor-interacting serine/threonine-protein kinase 2
Names
receptor-interacting protein 2
tyrosine-protein kinase RIPK2
NP_001316680.1
NP_620402.1
XP_006537740.1
XP_006537741.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329751.1NP_001316680.1  receptor-interacting serine/threonine-protein kinase 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL807379, BC058088
    Conserved Domains (2) summary
    cd08786
    Location:300385
    CARD_RIP2_CARD3; Caspase activation and recruitment domain of Receptor Interacting Protein 2
    cl21453
    Location:1166
    PKc_like; Protein Kinases, catalytic domain
  2. NM_138952.4NP_620402.1  receptor-interacting serine/threonine-protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_620402.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL807379, BC058088
    Consensus CDS
    CCDS17988.1
    UniProtKB/Swiss-Prot
    P58801
    UniProtKB/TrEMBL
    Q547H1
    Related
    ENSMUSP00000038833.6, ENSMUST00000037035.12
    Conserved Domains (2) summary
    cd08786
    Location:437522
    CARD_RIP2_CARD3; Caspase activation and recruitment domain of Receptor Interacting Protein 2
    cd14026
    Location:20303
    STKc_RIP2; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2

RNA

  1. NR_138102.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL807379, BC058088
    Related
    ENSMUST00000183871.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    16122740..16163674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537678.4XP_006537741.1  receptor-interacting serine/threonine-protein kinase 2 isoform X2

    Conserved Domains (2) summary
    cd08786
    Location:300385
    CARD_RIP2_CARD3; Caspase activation and recruitment domain of Receptor Interacting Protein 2
    cl21453
    Location:1166
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006537677.5XP_006537740.1  receptor-interacting serine/threonine-protein kinase 2 isoform X1

    Conserved Domains (2) summary
    cd08786
    Location:385470
    CARD_RIP2_CARD3; Caspase activation and recruitment domain of Receptor Interacting Protein 2
    cl21453
    Location:20251
    PKc_like; Protein Kinases, catalytic domain