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Ptprb protein tyrosine phosphatase, receptor type, B [ Mus musculus (house mouse) ]

Gene ID: 19263, updated on 12-Aug-2018

Summary

Official Symbol
Ptprbprovided by MGI
Official Full Name
protein tyrosine phosphatase, receptor type, Bprovided by MGI
Primary source
MGI:MGI:97809
See related
Ensembl:ENSMUSG00000020154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ptpz; Rptpb; Veptp; VE-PTP; C130094E24; 3230402H02Rik
Expression
Biased expression in lung adult (RPKM 33.0), subcutaneous fat pad adult (RPKM 10.1) and 12 other tissues See more
Orthologs

Genomic context

See Ptprb in Genome Data Viewer
Location:
10; 10 D2
Exon count:
35
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (116275513..116389538)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (115738430..115826594)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930422I22 gene Neighboring gene tetraspanin 8 Neighboring gene protein tyrosine phosphatase, receptor type, R Neighboring gene RIKEN cDNA 4933416C03 gene Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 1 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase beta
Names
R-PTP-beta
protein-tyrosine phosphatase beta
vascular endothelial protein tyrosine phosphatase
NP_084204.2
XP_006513441.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029928.2NP_084204.2  receptor-type tyrosine-protein phosphatase beta precursor

    See identical proteins and their annotated locations for NP_084204.2

    Status: VALIDATED

    Source sequence(s)
    AA790811, AC135862, AK137255, AK147668, BC141006
    Consensus CDS
    CCDS36063.1
    UniProtKB/Swiss-Prot
    B2RU80
    Related
    ENSMUSP00000089805.5, ENSMUST00000092167.6
    Conserved Domains (4) summary
    smart00194
    Location:17031961
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:17301961
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:111196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:12631345
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

    Range
    116275513..116389538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513378.3XP_006513441.1  receptor-type tyrosine-protein phosphatase beta isoform X1

    See identical proteins and their annotated locations for XP_006513441.1

    UniProtKB/TrEMBL
    A0A1W2P7W3
    Related
    ENSMUSP00000151821.1, ENSMUST00000218553.1
    Conserved Domains (5) summary
    smart00194
    Location:19902248
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:20172248
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:398483
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00161
    Location:2296
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00041
    Location:15501632
    fn3; Fibronectin type III domain
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