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Ptprb protein tyrosine phosphatase, receptor type, B [ Mus musculus (house mouse) ]

Gene ID: 19263, updated on 23-Jun-2021

Summary

Official Symbol
Ptprbprovided by MGI
Official Full Name
protein tyrosine phosphatase, receptor type, Bprovided by MGI
Primary source
MGI:MGI:97809
See related
Ensembl:ENSMUSG00000020154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VE-; Ptpz; Rptpb; Veptp; VE-PTP; C130094E24; 3230402H02Rik
Expression
Biased expression in lung adult (RPKM 33.0), subcutaneous fat pad adult (RPKM 10.1) and 12 other tissues See more
Orthologs
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Genomic context

See Ptprb in Genome Data Viewer
Location:
10; 10 D2
Exon count:
36
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (116111407..116225443)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (116275502..116389538)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (115738430..115826594)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930422I22 gene Neighboring gene tetraspanin 8 Neighboring gene protein tyrosine phosphatase, receptor type, R Neighboring gene Taf7l2 Neighboring gene predicted gene, 26495 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 1 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4 Neighboring gene predicted gene, 53634

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase beta
Names
R-PTP-beta
protein-tyrosine phosphatase beta
vascular endothelial protein tyrosine phosphatase
NP_084204.2
XP_006513441.1
XP_036011586.1
XP_036011587.1
XP_036011588.1
XP_036011589.1
XP_036011590.1
XP_036011591.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029928.2NP_084204.2  receptor-type tyrosine-protein phosphatase beta precursor

    See identical proteins and their annotated locations for NP_084204.2

    Status: VALIDATED

    Source sequence(s)
    AA790811, AC135862, AK137255, AK147668, BC141006
    Consensus CDS
    CCDS36063.1
    UniProtKB/Swiss-Prot
    B2RU80
    Related
    ENSMUSP00000089805.6, ENSMUST00000092167.7
    Conserved Domains (4) summary
    smart00194
    Location:17031961
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:17301961
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:111196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:12631345
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    116111407..116225443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155693.1XP_036011586.1  receptor-type tyrosine-protein phosphatase beta isoform X1

    Conserved Domains (6) summary
    cd00063
    Location:398483
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:158352
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14617
    Location:20192246
    R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B
    pfam00041
    Location:15501632
    fn3; Fibronectin type III domain
    pfam00652
    Location:2293
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam18861
    Location:17611931
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
  2. XM_036155695.1XP_036011588.1  receptor-type tyrosine-protein phosphatase beta isoform X4

    Conserved Domains (6) summary
    cd00063
    Location:398483
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:158352
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14617
    Location:19252152
    R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B
    pfam00041
    Location:15501629
    fn3; Fibronectin type III domain
    pfam00652
    Location:2293
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam18861
    Location:16671837
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
  3. XM_036155696.1XP_036011589.1  receptor-type tyrosine-protein phosphatase beta isoform X5

    Conserved Domains (6) summary
    cd00063
    Location:398483
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:158352
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14617
    Location:19252152
    R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B
    pfam00041
    Location:15501629
    fn3; Fibronectin type III domain
    pfam00652
    Location:2293
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam18861
    Location:16671837
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
  4. XM_036155694.1XP_036011587.1  receptor-type tyrosine-protein phosphatase beta isoform X2

    Conserved Domains (6) summary
    cd00063
    Location:398483
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:158352
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14617
    Location:20192246
    R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B
    pfam00041
    Location:15501632
    fn3; Fibronectin type III domain
    pfam00652
    Location:2293
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam18861
    Location:17611931
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
  5. XM_006513378.5XP_006513441.1  receptor-type tyrosine-protein phosphatase beta isoform X3

    See identical proteins and their annotated locations for XP_006513441.1

    UniProtKB/TrEMBL
    A0A1W2P7W3
    Related
    ENSMUSP00000151821.2, ENSMUST00000218553.2
    Conserved Domains (6) summary
    cd00063
    Location:398483
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:158352
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd14617
    Location:20192246
    R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B
    pfam00041
    Location:16441723
    fn3; Fibronectin type III domain
    pfam18861
    Location:17391933
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cl26069
    Location:2293
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  6. XM_036155697.1XP_036011590.1  receptor-type tyrosine-protein phosphatase beta isoform X6

    Conserved Domains (4) summary
    cd00063
    Location:111196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14617
    Location:17321959
    R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B
    pfam00041
    Location:12631345
    fn3; Fibronectin type III domain
    pfam18861
    Location:14741644
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
  7. XM_036155698.1XP_036011591.1  receptor-type tyrosine-protein phosphatase beta isoform X7

    Conserved Domains (4) summary
    cd00063
    Location:111196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14617
    Location:16381865
    R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B
    pfam00041
    Location:12631342
    fn3; Fibronectin type III domain
    pfam18861
    Location:13801550
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
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