Ptprb protein tyrosine phosphatase receptor type B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptprbprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Bprovided by MGI
Primary source: MGI:MGI:97809
See related: Ensembl:ENSMUSG00000020154 AllianceGenome:MGI:97809
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ptpz; Rptpb; Veptp; VE-PTP; C130094E24; 3230402H02Rik
Summary: Predicted to enable cadherin binding activity. Involved in angiogenesis and peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Predicted to be located in membrane. Predicted to be part of receptor complex. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in angiosarcoma; breast angiosarcoma; carcinoma (multiple); central nervous system cancer (multiple); and sarcoma. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 33.0), subcutaneous fat pad adult (RPKM 10.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 64.68 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (116111407..116225443)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (116275502..116389538)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava.
Title: Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava.
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration.
Title: Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration.
The Tyrosine Phosphatase hPTPRbeta Controls the Early Signals and Dopaminergic Cells Viability via the P2X7 Receptor.
Title: The Tyrosine Phosphatase hPTPRβ Controls the Early Signals and Dopaminergic Cells Viability via the P2X(7) Receptor.
The study provides evidence that PTPRB is an important regulator of TEK signaling in the aqueous humor outflow pathway, and it identifies a new therapeutic target for treatment of glaucoma.
Title: Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma.
This study provides the evidence to support a model whereby VE-PTP is a driver of diabetic nephropathy and shows that VE-PTP inhibition is a promising vasculoprotective strategy for the kidney in diabetes.
Title: Targeting VE-PTP phosphatase protects the kidney from diabetic injury.
VEPTP (vascular endothelial protein tyrosine phosphatase) determines TIE2 response to ANGPT2. VEPTP is absent from lymphatic endothelium in mouse in vivo, permitting ANGPT2/TIE2-mediated lymphangiogenesis.
Title: Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.
PTPRB regulates branching morphogenesis in the mammary epithelium by modulating the response of the FGFR signalling pathway to FGF stimulation
Title: The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis.
STIM1-induced Ca(2+) signaling activates Pyk2 to inhibit the interaction of VE-PTP and VE-cadherin and hence increase endothelial permeability.
Title: Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca(2+) entry regulates disassembly of adherens junctions.
In the absence of Tie-2, VE-PTP inhibition destabilizes endothelial barrier integrity in agreement with the VE-cadherin-supportive effect of VE-PTP.
Title: Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin.
The Lewis X epitope is mainly expressed on phosphacan/receptor protein tyrosine phosphatase beta (RPTPbeta) in the developing mouse brain.
Title: Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPβ.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit46 (e-PCR), detects polymorphism
- UniSTS:126225

D10Mit295 (e-PCR), detects polymorphism
- UniSTS:126199

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in glial cell migration	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase beta

Names: R-PTP-beta; protein-tyrosine phosphatase beta; vascular endothelial protein tyrosine phosphatase

NP_084204.2

EC 3.1.3.48

XP_006513441.1

EC 3.1.3.48

XP_036011586.1

EC 3.1.3.48

XP_036011587.1

EC 3.1.3.48

XP_036011588.1

EC 3.1.3.48

XP_036011589.1

EC 3.1.3.48

XP_036011590.1

EC 3.1.3.48

XP_036011591.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429496.1 → NP_001416425.1 receptor-type tyrosine-protein phosphatase beta isoform 2

Status: VALIDATED

Source sequence(s)

AC135862, AC166836

UniProtKB/TrEMBL

A0A1W2P7W3
NM_029928.2 → NP_084204.2 receptor-type tyrosine-protein phosphatase beta isoform 1 precursor

See identical proteins and their annotated locations for NP_084204.2

Status: VALIDATED

Source sequence(s)

AA790811, AC135862, AK137255, AK147668, BC141006

Consensus CDS

CCDS36063.1

UniProtKB/Swiss-Prot

B2RU80, Q3UGZ7, Q8CIW2

Related

ENSMUSP00000089805.6, ENSMUST00000092167.7

Conserved Domains (4) summary

smart00194
Location:1703 → 1961

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1730 → 1961

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:111 → 196

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:1263 → 1345

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

116111407..116225443

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155693.1 → XP_036011586.1 receptor-type tyrosine-protein phosphatase beta isoform X1

Conserved Domains (6) summary

cd00063
Location:398 → 483

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam05109
Location:158 → 352

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14617
Location:2019 → 2246

R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B

pfam00041
Location:1550 → 1632

fn3; Fibronectin type III domain

pfam00652
Location:22 → 93

Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

pfam18861
Location:1761 → 1931

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
XM_036155695.1 → XP_036011588.1 receptor-type tyrosine-protein phosphatase beta isoform X4

Conserved Domains (6) summary

cd00063
Location:398 → 483

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam05109
Location:158 → 352

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14617
Location:1925 → 2152

R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B

pfam00041
Location:1550 → 1629

fn3; Fibronectin type III domain

pfam00652
Location:22 → 93

Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

pfam18861
Location:1667 → 1837

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
XM_036155696.1 → XP_036011589.1 receptor-type tyrosine-protein phosphatase beta isoform X5

Conserved Domains (6) summary

cd00063
Location:398 → 483

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam05109
Location:158 → 352

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14617
Location:1925 → 2152

R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B

pfam00041
Location:1550 → 1629

fn3; Fibronectin type III domain

pfam00652
Location:22 → 93

Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

pfam18861
Location:1667 → 1837

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
XM_036155694.1 → XP_036011587.1 receptor-type tyrosine-protein phosphatase beta isoform X2

Conserved Domains (6) summary

cd00063
Location:398 → 483

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam05109
Location:158 → 352

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14617
Location:2019 → 2246

R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B

pfam00041
Location:1550 → 1632

fn3; Fibronectin type III domain

pfam00652
Location:22 → 93

Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

pfam18861
Location:1761 → 1931

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
XM_006513378.5 → XP_006513441.1 receptor-type tyrosine-protein phosphatase beta isoform X3

Related

ENSMUSP00000151821.2, ENSMUST00000218553.2

Conserved Domains (6) summary

cd00063
Location:398 → 483

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam05109
Location:158 → 352

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14617
Location:2019 → 2246

R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B

pfam00041
Location:1644 → 1723

fn3; Fibronectin type III domain

pfam18861
Location:1739 → 1933

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cl26069
Location:22 → 93

Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
XM_036155697.1 → XP_036011590.1 receptor-type tyrosine-protein phosphatase beta isoform X6

Conserved Domains (4) summary

cd00063
Location:111 → 196

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14617
Location:1732 → 1959

R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B

pfam00041
Location:1263 → 1345

fn3; Fibronectin type III domain

pfam18861
Location:1474 → 1644

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
XM_036155698.1 → XP_036011591.1 receptor-type tyrosine-protein phosphatase beta isoform X7

Conserved Domains (4) summary

cd00063
Location:111 → 196

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14617
Location:1638 → 1865

R-PTPc-B; catalytic domain of receptor-type tyrosine-protein phosphatase B

pfam00041
Location:1263 → 1342

fn3; Fibronectin type III domain

pfam18861
Location:1380 → 1550

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J