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Sirpa signal-regulatory protein alpha [ Mus musculus (house mouse) ]

Gene ID: 19261, updated on 18-Dec-2018

Summary

Official Symbol
Sirpaprovided by MGI
Official Full Name
signal-regulatory protein alphaprovided by MGI
Primary source
MGI:MGI:108563
See related
Ensembl:ENSMUSG00000037902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; AI835480
Expression
Broad expression in cortex adult (RPKM 59.8), frontal lobe adult (RPKM 57.5) and 25 other tissues See more
Orthologs

Genomic context

See Sirpa in Genome Data Viewer
Location:
2 F1; 2 63.19 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (129592665..129632228)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (129418575..129457964)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F830045P16 gene Neighboring gene predicted gene 14040 Neighboring gene predicted gene 14041 Neighboring gene prodynorphin Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene 2_1620.1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase regulator activity ISO
Inferred from Sequence Orthology
more info
 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion mediator activity ISO
Inferred from Sequence Orthology
more info
 
protein antigen binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylated amino acid binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-12 ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
granulocyte migration IGI
Inferred from Genetic Interaction
more info
PubMed 
hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocyte extravasation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of I-kappaB phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of chemokine (C-C motif) ligand 5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytokine production involved in inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macrophage inflammatory protein 1 alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis, engulfment IDA
Inferred from Direct Assay
more info
PubMed 
phagocytosis, recognition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type substrate 1
Names
CD172 antigen-like family member A
SHP substrate 1
brain Ig-like molecule with tyrosine-based activation motifs
brain immunological-like with tyrosine-based motifs
inhibitory receptor SHPS-1
mSIRP-alpha1
myD-1 antigen
protein tyrosine phosphatase, non-receptor type substrate 1
signal-regulatory protein alpha-1
sirp-alpha-1
NP_001171118.1
NP_001277948.1
NP_001277949.1
NP_001277950.1
NP_001277951.1
NP_031573.2
XP_006499049.1
XP_017172050.1
XP_017172053.1
XP_017172057.1
XP_017172058.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177647.2NP_001171118.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001171118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (2) is shorter than isoform 3.
    Source sequence(s)
    AF072544, AK159617, BM899883, CD578948
    Consensus CDS
    CCDS50708.1
    UniProtKB/Swiss-Prot
    P97797
    UniProtKB/TrEMBL
    A0A0R4J1Z7
    Related
    ENSMUSP00000125004.1, ENSMUST00000160276.1
    Conserved Domains (2) summary
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    pfam07686
    Location:38146
    V-set; Immunoglobulin V-set domain
  2. NM_001291019.1NP_001277948.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001277948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3). Both variants 4 and 5 encode isoform 3.
    Source sequence(s)
    AB018194, AK159617, BM899883, CD578948
    Consensus CDS
    CCDS71142.1
    UniProtKB/Swiss-Prot
    P97797
    UniProtKB/TrEMBL
    E0CYM8
    Related
    ENSMUSP00000049022.7, ENSMUST00000049262.13
    Conserved Domains (4) summary
    cd00098
    Location:257336
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    pfam07686
    Location:38146
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:145255
    Ig; Immunoglobulin domain
  3. NM_001291020.1NP_001277949.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001277949.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Both variants 4 and 5 encode isoform 3.
    Source sequence(s)
    AB018194, AK159617, BM899883
    Consensus CDS
    CCDS71142.1
    UniProtKB/Swiss-Prot
    P97797
    UniProtKB/TrEMBL
    E0CYM8
    Related
    ENSMUSP00000124048.1, ENSMUST00000161620.7
    Conserved Domains (4) summary
    cd00098
    Location:257336
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    pfam07686
    Location:38146
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:145255
    Ig; Immunoglobulin domain
  4. NM_001291021.1NP_001277950.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (4) that is shorter than isoform 3.
    Source sequence(s)
    AK159617, BM899883, CD578948, CX236057
    Consensus CDS
    CCDS71143.1
    UniProtKB/TrEMBL
    E9QPT7
    Related
    ENSMUSP00000096713.3, ENSMUST00000099113.9
    Conserved Domains (2) summary
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    pfam07686
    Location:38146
    V-set; Immunoglobulin V-set domain
  5. NM_001291022.1NP_001277951.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 5' coding region and two in-frame exons in the central coding region, and also uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (5) is shorter than isoform 3.
    Source sequence(s)
    AK159617, BM899883, CD578948, CJ151068
    Consensus CDS
    CCDS79845.1
    UniProtKB/TrEMBL
    E0CX65
    Related
    ENSMUSP00000124888.1, ENSMUST00000163034.7
  6. NM_001355158.1NP_001342087.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AL808126
    Conserved Domains (3) summary
    cd05772
    Location:148251
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:253356
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cl11960
    Location:35146
    Ig; Immunoglobulin domain
  7. NM_001355160.1NP_001342089.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL808126
    Conserved Domains (3) summary
    cd05772
    Location:136239
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:241344
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cl11960
    Location:23134
    Ig; Immunoglobulin domain
  8. NM_007547.4NP_031573.2  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_031573.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4, resulting in an isoform (1) that is shorter than isoform 3. Variants 1 and 8 both encode the same isoform (1).
    Source sequence(s)
    AF072543, AK159617, BM899883, CD578948
    Consensus CDS
    CCDS16729.1
    UniProtKB/Swiss-Prot
    P97797
    UniProtKB/TrEMBL
    Q6P6I8
    Related
    ENSMUSP00000099491.3, ENSMUST00000103202.9
    Conserved Domains (3) summary
    cd05772
    Location:148251
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:253356
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cl11960
    Location:35146
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    129592665..129632228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316568.1XP_017172057.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X4

    UniProtKB/TrEMBL
    E9QPT7
    Conserved Domains (2) summary
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    pfam07686
    Location:38146
    V-set; Immunoglobulin V-set domain
  2. XM_017316564.1XP_017172053.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

    Conserved Domains (4) summary
    cd00098
    Location:250329
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:34138
    IG_like; Immunoglobulin like
    pfam07686
    Location:31139
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:138248
    Ig; Immunoglobulin domain
  3. XM_017316561.1XP_017172050.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

    UniProtKB/Swiss-Prot
    P97797
    UniProtKB/TrEMBL
    Q6P6I8
    Related
    ENSMUSP00000137611.1, ENSMUST00000179001.7
    Conserved Domains (3) summary
    cd05772
    Location:148251
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:253356
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cl11960
    Location:35146
    Ig; Immunoglobulin domain
  4. XM_017316569.1XP_017172058.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5

    UniProtKB/Swiss-Prot
    P97797
    UniProtKB/TrEMBL
    A0A0R4J1Z7
    Conserved Domains (2) summary
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    pfam07686
    Location:38146
    V-set; Immunoglobulin V-set domain
  5. XM_006498986.3XP_006499049.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

    See identical proteins and their annotated locations for XP_006499049.1

    UniProtKB/TrEMBL
    E0CYM8
    Conserved Domains (4) summary
    cd00098
    Location:257336
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    pfam07686
    Location:38146
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:145255
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177646.1: Suppressed sequence

    Description
    NM_001177646.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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