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Ptpn5 protein tyrosine phosphatase, non-receptor type 5 [ Mus musculus (house mouse) ]

Gene ID: 19259, updated on 7-Apr-2025

Summary

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Official Symbol
Ptpn5provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 5provided by MGI
Primary source
MGI:MGI:97807
See related
Ensembl:ENSMUSG00000030854 AllianceGenome:MGI:97807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Step
Summary
Enables protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in several cellular components, including perikaryon; proximal dendrite; and synaptic vesicle. Predicted to be active in cell junction; cytosol; and plasma membrane. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; retina; and submandibular gland. Orthologous to human PTPN5 (protein tyrosine phosphatase non-receptor type 5). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in CNS E18 (RPKM 44.4), whole brain E14.5 (RPKM 40.6) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Ptpn5 in Genome Data Viewer
Location:
7 B3; 7 30.7 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46727543..46783774, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (47077795..47134026, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily member 22-like Neighboring gene transmembrane protein 86A Neighboring gene microRNA 7056 Neighboring gene STARR-seq mESC enhancer starr_18879 Neighboring gene STARR-positive B cell enhancer ABC_E4928 Neighboring gene predicted gene 14377 Neighboring gene STARR-seq mESC enhancer starr_18880 Neighboring gene STARR-positive B cell enhancer mm9_chr7:54405971-54406272 Neighboring gene MAS-related GPR, member A6 Neighboring gene MAS-related GPR, member A1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases. Sharma E, et al. Brain Res Mol Brain Res, 1995 Aug. PMID 7494467
  2. The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications. Carty NC, et al. Transl Psychiatry, 2012 Jul 10. PMID 22781170, Free PMC Article
  3. Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory. Venkitaramani DV, et al. Eur J Neurosci, 2011 Jun. PMID 21501258, Free PMC Article
  4. Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase. Hicklin TR, et al. Proc Natl Acad Sci U S A, 2011 Apr 19. PMID 21464302, Free PMC Article
  5. Tyrosine phosphatase STEP61 negatively regulates amyloid β-mediated ERK/CREB signaling pathways via α7 nicotinic acetylcholine receptors. Zhang L, et al. J Neurosci Res, 2013 Dec. PMID 24123152

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.
    Title: Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.
  2. Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology.
    Title: Tyrosine phosphatase STEP(61) in human dementia and in animal models with amyloid and tau pathology.
  3. Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner.
    Title: Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP(61)) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner.
  4. Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP.
    Title: Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP.
  5. Levels of Ptpn5 protein are elevated in a mouse model of sepsis-associated encephalopathy with associated decreases in phosphorylated forms of GluN2B, CREB, PSD95, ERK1, BDNF, and ERK2.
    Title: Disruption of Striatal-Enriched Protein Tyrosine Phosphatase Signaling Might Contribute to Memory Impairment in a Mouse Model of Sepsis-Associated Encephalopathy.
  6. Deletion of STEP has a beneficial effect on motor coordination and cognition in a mouse model of Huntington's disease.
    Title: Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease.
  7. STEP61 undergoes proteolytic degradation in conditions leading to synaptic strengthening and memory formation
    Title: Proteolytic Degradation of Hippocampal STEP(61) in LTP and Learning.
  8. activation of synaptic NMDAR by bicuculline or D-serine results in the ubiquitination and proteasomal degradation of STEP61, and increased surface localization of GluN1/GluN2B receptors.
    Title: Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP(61).
  9. STEP plays an important role at nerve terminals in the regulation of Ca(2+) homeostasis and neurotransmitter release.
    Title: Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice.
  10. STEP61 degradation is an important event in BDNF-mediated effects.
    Title: BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in exploration behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of response to drug ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to immobilization stress ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in proximal dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 5
Names
neural-specific protein-tyrosine phosphatase
striatum-enriched protein-tyrosine phosphatase
NP_001157037.1
NP_001404109.1
NP_038671.2
XP_006540776.1
XP_006540777.1
XP_017177535.1
XP_030098098.1
XP_036008691.1
XP_036008692.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163565.2 → NP_001157037.1  tyrosine-protein phosphatase non-receptor type 5

    See identical proteins and their annotated locations for NP_001157037.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All three variants encode the same protein.
    Source sequence(s)
    AC113001
    Consensus CDS
    CCDS21294.1
    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Related
    ENSMUSP00000033142.6, ENSMUST00000033142.13
    Conserved Domains (1) summary
    cd14613
    Location:274 → 531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  2. NM_001417180.1 → NP_001404109.1  tyrosine-protein phosphatase non-receptor type 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC113001
    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9

  3. NM_013643.3 → NP_038671.2  tyrosine-protein phosphatase non-receptor type 5

    See identical proteins and their annotated locations for NP_038671.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All three variants encode the same protein.
    Source sequence(s)
    AC113001
    Consensus CDS
    CCDS21294.1
    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Related
    ENSMUSP00000099686.2, ENSMUST00000102626.10
    Conserved Domains (1) summary
    cd14613
    Location:274 → 531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46727543..46783774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242238.1 → XP_030098098.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274 → 531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  2. XM_006540714.4 → XP_006540777.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    See identical proteins and their annotated locations for XP_006540777.1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274 → 531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  3. XM_006540713.4 → XP_006540776.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    See identical proteins and their annotated locations for XP_006540776.1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274 → 531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  4. XM_036152798.1 → XP_036008691.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274 → 531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  5. XM_036152799.1 → XP_036008692.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274 → 531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

  6. XM_017322046.2 → XP_017177535.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274 → 531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54830.2 GenPept UniProtKB/Swiss-Prot:P54830

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