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Ptpn5 protein tyrosine phosphatase, non-receptor type 5 [ Mus musculus (house mouse) ]

Gene ID: 19259, updated on 9-Jun-2024

Summary

Official Symbol
Ptpn5provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 5provided by MGI
Primary source
MGI:MGI:97807
See related
Ensembl:ENSMUSG00000030854 AllianceGenome:MGI:97807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Step
Summary
Enables protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in several cellular components, including perikaryon; proximal dendrite; and synaptic vesicle. Is expressed in several structures, including central nervous system; dorsal root ganglion; reproductive system; retina; and submandibular gland. Orthologous to human PTPN5 (protein tyrosine phosphatase non-receptor type 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 44.4), whole brain E14.5 (RPKM 40.6) and 9 other tissues See more
Orthologs
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Genomic context

See Ptpn5 in Genome Data Viewer
Location:
7 B3; 7 30.7 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46727543..46783774, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (47077795..47134026, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily member 22-like Neighboring gene transmembrane protein 86A Neighboring gene microRNA 7056 Neighboring gene STARR-seq mESC enhancer starr_18879 Neighboring gene STARR-positive B cell enhancer ABC_E4928 Neighboring gene predicted gene 14377 Neighboring gene STARR-seq mESC enhancer starr_18880 Neighboring gene STARR-positive B cell enhancer mm9_chr7:54405971-54406272 Neighboring gene MAS-related GPR, member A6 Neighboring gene MAS-related GPR, member A1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in proximal dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 5
Names
neural-specific protein-tyrosine phosphatase
striatum-enriched protein-tyrosine phosphatase
NP_001157037.1
NP_001404109.1
NP_038671.2
XP_006540776.1
XP_006540777.1
XP_017177535.1
XP_030098098.1
XP_036008691.1
XP_036008692.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163565.2NP_001157037.1  tyrosine-protein phosphatase non-receptor type 5

    See identical proteins and their annotated locations for NP_001157037.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All three variants encode the same protein.
    Source sequence(s)
    AC113001
    Consensus CDS
    CCDS21294.1
    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Related
    ENSMUSP00000033142.6, ENSMUST00000033142.13
    Conserved Domains (1) summary
    cd14613
    Location:274531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
  2. NM_001417180.1NP_001404109.1  tyrosine-protein phosphatase non-receptor type 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC113001
    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
  3. NM_013643.3NP_038671.2  tyrosine-protein phosphatase non-receptor type 5

    See identical proteins and their annotated locations for NP_038671.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All three variants encode the same protein.
    Source sequence(s)
    AC113001
    Consensus CDS
    CCDS21294.1
    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Related
    ENSMUSP00000099686.2, ENSMUST00000102626.10
    Conserved Domains (1) summary
    cd14613
    Location:274531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46727543..46783774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242238.1XP_030098098.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
  2. XM_006540714.4XP_006540777.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    See identical proteins and their annotated locations for XP_006540777.1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
  3. XM_006540713.4XP_006540776.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    See identical proteins and their annotated locations for XP_006540776.1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
  4. XM_036152798.1XP_036008691.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
  5. XM_036152799.1XP_036008692.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
  6. XM_017322046.2XP_017177535.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

    UniProtKB/Swiss-Prot
    P54830, Q64694, Q8CAN0
    UniProtKB/TrEMBL
    Q80WU9
    Conserved Domains (1) summary
    cd14613
    Location:274531
    PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5