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Ptpn2 protein tyrosine phosphatase, non-receptor type 2 [ Mus musculus (house mouse) ]

Gene ID: 19255, updated on 8-Jun-2019

Summary

Official Symbol
Ptpn2provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 2provided by MGI
Primary source
MGI:MGI:97806
See related
Ensembl:ENSMUSG00000024539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ptpt; TC-PTP; AI325124
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.3), CNS E14 (RPKM 3.0) and 27 other tissues See more
Orthologs

Genomic context

See Ptpn2 in Genome Data Viewer
Location:
18; 18 E1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (67665501..67724758, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (67825155..67884275, complement)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene centrosomal protein 76 Neighboring gene proteasome (prosome, macropain) assembly chaperone 2 Neighboring gene predicted gene, 46626 Neighboring gene predicted gene, 26910 Neighboring gene SEH1-like (S. cerevisiae

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
STAT family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
non-membrane spanning protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interferon-gamma-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-2-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-2-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-4-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-4-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macrophage colony-stimulating factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of positive thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
PubMed 
negative regulation of tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of PERK-mediated unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 2
Names
MPTP
T cell protein-tyrosine phosphatase
protein-tyrosine phosphatase PTP-2
NP_001120649.1
NP_033003.1
XP_006525786.1
XP_011245160.1
XP_011245161.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127177.1NP_001120649.1  tyrosine-protein phosphatase non-receptor type 2 isoform b

    See identical proteins and their annotated locations for NP_001120649.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript.
    Source sequence(s)
    AC108434, AK014528, AK076072, AK132013, CA560046, DV552728
    Consensus CDS
    CCDS50311.1
    UniProtKB/Swiss-Prot
    Q06180
    Related
    ENSMUSP00000112675.1, ENSMUST00000122412.1
    Conserved Domains (2) summary
    smart00194
    Location:5274
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:45274
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_008977.3NP_033003.1  tyrosine-protein phosphatase non-receptor type 2 isoform a

    See identical proteins and their annotated locations for NP_033003.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and has multiple coding region differences, compared to variant 2. The resulting protein (isoform a) has a distinct C-terminus and is shorter than isoform b.
    Source sequence(s)
    AK014528, AK076072, CA560046, DV552728
    Consensus CDS
    CCDS37851.1
    UniProtKB/Swiss-Prot
    Q06180
    Related
    ENSMUSP00000025420.7, ENSMUST00000025420.13
    Conserved Domains (2) summary
    smart00194
    Location:5274
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:45274
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    67665501..67724758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246858.2XP_011245160.1  tyrosine-protein phosphatase non-receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_011245160.1

    UniProtKB/Swiss-Prot
    Q06180
    Conserved Domains (2) summary
    smart00194
    Location:5274
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:45274
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_006525723.1XP_006525786.1  tyrosine-protein phosphatase non-receptor type 2 isoform X2

    See identical proteins and their annotated locations for XP_006525786.1

    Conserved Domains (2) summary
    cd00047
    Location:1175
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:1175
    Y_phosphatase; Protein-tyrosine phosphatase
  3. XM_011246859.1XP_011245161.1  tyrosine-protein phosphatase non-receptor type 2 isoform X2

    See identical proteins and their annotated locations for XP_011245161.1

    Conserved Domains (2) summary
    cd00047
    Location:1175
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:1175
    Y_phosphatase; Protein-tyrosine phosphatase
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