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Ptp4a3 protein tyrosine phosphatase 4a3 [ Mus musculus (house mouse) ]

Gene ID: 19245, updated on 7-Jan-2023

Summary

Official Symbol
Ptp4a3provided by MGI
Official Full Name
protein tyrosine phosphatase 4a3provided by MGI
Primary source
MGI:MGI:1277098
See related
Ensembl:ENSMUSG00000059895 AllianceGenome:MGI:1277098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prl-3; pPtp4a3
Summary
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of vascular permeability; and regulation of vascular endothelial growth factor signaling pathway. Predicted to be located in endosome and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; liver; metanephros; and retina layer. Orthologous to human PTP4A3 (protein tyrosine phosphatase 4A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 91.4), heart adult (RPKM 60.2) and 26 other tissues See more
Orthologs
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Genomic context

See Ptp4a3 in Genome Data Viewer
Location:
15; 15 D3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (73594994..73630615)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (73723145..73758766)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 45, member 4 Neighboring gene G protein-coupled receptor 20 Neighboring gene predicted gene, 22106 Neighboring gene maestro heat-like repeat family member 5 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4C Neighboring gene predicted gene 6569

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein tyrosine phosphatase type IVA 3
Names
protein-tyrosine phosphatase of regenerating liver 3
NP_001159860.1
NP_001159861.1
NP_001159862.1
NP_001344520.1
NP_033001.2
XP_006520705.1
XP_011243825.1
XP_030104287.1
XP_036015165.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166388.2NP_001159860.1  protein tyrosine phosphatase type IVA 3 isoform 1

    See identical proteins and their annotated locations for NP_001159860.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC119884
    Consensus CDS
    CCDS27519.1
    UniProtKB/Swiss-Prot
    Q9CTC8, Q9D658
    UniProtKB/TrEMBL
    A0A6P5QWG8, A0A8C6HIV7
    Related
    ENSMUSP00000131281.2, ENSMUST00000163582.9
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. NM_001166389.2NP_001159861.1  protein tyrosine phosphatase type IVA 3 isoform 1

    See identical proteins and their annotated locations for NP_001159861.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR exon, as compared to variant 1 has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.
    Source sequence(s)
    AC119884
    Consensus CDS
    CCDS27519.1
    UniProtKB/Swiss-Prot
    Q9CTC8, Q9D658
    UniProtKB/TrEMBL
    A0A6P5QWG8, A0A8C6HIV7
    Related
    ENSMUSP00000132097.2, ENSMUST00000165541.8
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  3. NM_001166390.2NP_001159862.1  protein tyrosine phosphatase type IVA 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' sequence, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC119884
    UniProtKB/Swiss-Prot
    Q9D658
    UniProtKB/TrEMBL
    A0A8C6MYR5, E9PXS4
    Related
    ENSMUSP00000131036.2, ENSMUST00000167582.8
    Conserved Domains (1) summary
    cl21483
    Location:18154
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. NM_001357591.2NP_001344520.1  protein tyrosine phosphatase type IVA 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.
    Source sequence(s)
    AC119884
    Consensus CDS
    CCDS27519.1
    UniProtKB/Swiss-Prot
    Q9CTC8
    UniProtKB/TrEMBL
    A0A6P5QWG8, A0A8C6HIV7
    Related
    ENSMUSP00000154829.2, ENSMUST00000230177.2
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  5. NM_001411696.1NP_001398625.1  protein tyrosine phosphatase type IVA 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.
    Source sequence(s)
    AC119884
    UniProtKB/Swiss-Prot
    Q9CTC8
    UniProtKB/TrEMBL
    A0A6P5QWG8, A0A8C6HIV7
  6. NM_001411697.1NP_001398626.1  protein tyrosine phosphatase type IVA 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.
    Source sequence(s)
    AC119884
    UniProtKB/Swiss-Prot
    Q9CTC8
    UniProtKB/TrEMBL
    A0A6P5QWG8, A0A8C6HIV7
  7. NM_001411698.1NP_001398627.1  protein tyrosine phosphatase type IVA 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.
    Source sequence(s)
    AC119884
    UniProtKB/Swiss-Prot
    Q9CTC8
    UniProtKB/TrEMBL
    A0A6P5QWG8, A0A8C6HIV7
  8. NM_001411699.1NP_001398628.1  protein tyrosine phosphatase type IVA 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.
    Source sequence(s)
    AC119884
    UniProtKB/Swiss-Prot
    Q9CTC8
    UniProtKB/TrEMBL
    A0A6P5QWG8, A0A8C6HIV7
  9. NM_001411700.1NP_001398629.1  protein tyrosine phosphatase type IVA 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.
    Source sequence(s)
    AC119884
    UniProtKB/Swiss-Prot
    Q9CTC8
    UniProtKB/TrEMBL
    A0A6P5QWG8, A0A8C6HIV7
  10. NM_008975.4NP_033001.2  protein tyrosine phosphatase type IVA 3 isoform 1

    See identical proteins and their annotated locations for NP_033001.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1, and encodes isoform 1.
    Source sequence(s)
    AC119884
    Consensus CDS
    CCDS27519.1
    UniProtKB/Swiss-Prot
    Q9CTC8, Q9D658
    UniProtKB/TrEMBL
    A0A6P5QWG8, A0A8C6HIV7
    Related
    ENSMUSP00000060956.7, ENSMUST00000053232.8
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RNA

  1. NR_177452.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) has an alternate 5' UTR exon and skips an internal exon, as compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC119884

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    73594994..73630615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248427.2XP_030104287.1  protein tyrosine phosphatase type IVA 3 isoform X1

    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. XM_006520642.1XP_006520705.1  protein tyrosine phosphatase type IVA 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9D658
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  3. XM_011245523.2XP_011243825.1  protein tyrosine phosphatase type IVA 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9D658
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  4. XM_036159272.1XP_036015165.1  protein tyrosine phosphatase type IVA 3 isoform X1

    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily