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Tmsb10 thymosin beta 10 [ Mus musculus (house mouse) ]

Gene ID: 19240, updated on 22-Nov-2022

Summary

Official Symbol
Tmsb10provided by MGI
Official Full Name
thymosin beta 10provided by MGI
Primary source
MGI:MGI:109146
See related
Ensembl:ENSMUSG00000079523 AllianceGenome:MGI:109146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tb10; Ptmb10
Summary
Predicted to enable actin monomer binding activity. Predicted to be involved in regulation of cell migration and sequestering of actin monomers. Predicted to act upstream of or within actin cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Orthologous to human TMSB10 (thymosin beta 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 401.3), CNS E14 (RPKM 333.4) and 14 other tissues See more
Orthologs
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Genomic context

See Tmsb10 in Genome Data Viewer
Location:
6; 6 C1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72934330..72935731, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72957347..72958748, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene potassium channel modulatory factor 1 Neighboring gene transfer RNA serine (anticodon GCU) Neighboring gene mediator complex subunit 29 pseudogene Neighboring gene predicted gene, 31547

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin monomer binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IC
Inferred by Curator
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039392.3NP_001034481.1  thymosin beta-10

    See identical proteins and their annotated locations for NP_001034481.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC153842
    Consensus CDS
    CCDS39519.1
    UniProtKB/Swiss-Prot
    Q3V2M3, Q6ZWY8
    UniProtKB/TrEMBL
    A0A6P5PYA2, A0A8C6GLM7, A6H6H4, J3QK33
    Related
    ENSMUSP00000109683.2, ENSMUST00000114049.2
    Conserved Domains (1) summary
    pfam01290
    Location:341
    Thymosin; Thymosin beta-4 family
  2. NM_001190327.1NP_001177256.1  thymosin beta-10

    See identical proteins and their annotated locations for NP_001177256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC153842, AK003178
    Consensus CDS
    CCDS39519.1
    UniProtKB/Swiss-Prot
    Q3V2M3, Q6ZWY8
    UniProtKB/TrEMBL
    A0A6P5PYA2, A0A8C6GLM7, A6H6H4, J3QK33
    Related
    ENSMUSP00000109682.2, ENSMUST00000114048.2
    Conserved Domains (1) summary
    pfam01290
    Location:341
    Thymosin; Thymosin beta-4 family
  3. NM_025284.5NP_079560.1  thymosin beta-10

    See identical proteins and their annotated locations for NP_079560.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC153842
    Consensus CDS
    CCDS39519.1
    UniProtKB/Swiss-Prot
    Q3V2M3, Q6ZWY8
    UniProtKB/TrEMBL
    A0A6P5PYA2, A0A8C6GLM7, A6H6H4, J3QK33
    Related
    ENSMUSP00000109684.2, ENSMUST00000114050.8
    Conserved Domains (1) summary
    pfam01290
    Location:341
    Thymosin; Thymosin beta-4 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72934330..72935731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)