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Tmsb10 thymosin beta 10 [ Mus musculus (house mouse) ]

Gene ID: 19240, updated on 17-Aug-2024

Summary

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Official Symbol
Tmsb10provided by MGI
Official Full Name
thymosin beta 10provided by MGI
Primary source
MGI:MGI:109146
See related
Ensembl:ENSMUSG00000079523 AllianceGenome:MGI:109146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tb10; Ptmb10
Summary
Predicted to enable actin monomer binding activity. Predicted to be involved in regulation of cell migration and sequestering of actin monomers. Predicted to act upstream of or within actin cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Orthologous to human TMSB10 (thymosin beta 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 401.3), CNS E14 (RPKM 333.4) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 C1; 6 32.35 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72934330..72935731, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72957347..72958748, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16319 Neighboring gene STARR-seq mESC enhancer starr_16322 Neighboring gene potassium channel modulatory factor 1 Neighboring gene STARR-seq mESC enhancer starr_16325 Neighboring gene STARR-seq mESC enhancer starr_16327 Neighboring gene STARR-seq mESC enhancer starr_16328 Neighboring gene nuclear encoded tRNA serine 9 (anticodon GCT) Neighboring gene STARR-seq mESC enhancer starr_16329 Neighboring gene mediator complex subunit 29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16330 Neighboring gene predicted gene, 31547

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The beta-thymosins, small actin-binding peptides widely expressed in the developing and adult cerebellum. Gómez-Márquez J, et al. Cerebellum, 2002 Apr. PMID 12882358
  2. Quantitative analysis of thymosin beta-10 messenger RNA in thyroid carcinomas. Takano T, et al. Jpn J Clin Oncol, 2002 Jul. PMID 12324571
  3. Thymosin beta10 mRNA expression during early postimplantation mouse development. Carpintero P, et al. FEBS Lett, 1996 Sep 23. PMID 8925915
  4. The expression and function of thymosin beta 10 in tooth germ development. Shiotsuka M, et al. Int J Dev Biol, 2013. PMID 24623079
  5. Upregulation of thymosin beta-10 by Mycobacterium bovis infection of bovine macrophages is associated with apoptosis. Gutiérrez-Pabello JA, et al. Infect Immun, 2002 Apr. PMID 11895978, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tbeta10 has multiple functions in the developmental course from initiation to root formation of the tooth germ
    Title: The expression and function of thymosin beta 10 in tooth germ development.
  2. We found an increased expression of thymosin beta-10 mRNA in thyroid carcinomas, especially in anaplastic carcinomas.
    Title: Quantitative analysis of thymosin beta-10 messenger RNA in thyroid carcinomas.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
thymosin beta-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039392.3 → NP_001034481.1  thymosin beta-10

    See identical proteins and their annotated locations for NP_001034481.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC153842
    Consensus CDS
    CCDS39519.1
    UniProtKB/Swiss-Prot
    Q3V2M3, Q6ZWY8
    UniProtKB/TrEMBL
    A6H6H4, J3QK33
    Related
    ENSMUSP00000109683.2, ENSMUST00000114049.2
    Conserved Domains (1) summary
    pfam01290
    Location:3 → 41
    Thymosin; Thymosin beta-4 family

  2. NM_001190327.1 → NP_001177256.1  thymosin beta-10

    See identical proteins and their annotated locations for NP_001177256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC153842, AK003178
    Consensus CDS
    CCDS39519.1
    UniProtKB/Swiss-Prot
    Q3V2M3, Q6ZWY8
    UniProtKB/TrEMBL
    A6H6H4, J3QK33
    Related
    ENSMUSP00000109682.2, ENSMUST00000114048.2
    Conserved Domains (1) summary
    pfam01290
    Location:3 → 41
    Thymosin; Thymosin beta-4 family

  3. NM_025284.5 → NP_079560.1  thymosin beta-10

    See identical proteins and their annotated locations for NP_079560.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC153842
    Consensus CDS
    CCDS39519.1
    UniProtKB/Swiss-Prot
    Q3V2M3, Q6ZWY8
    UniProtKB/TrEMBL
    A6H6H4, J3QK33
    Related
    ENSMUSP00000109684.2, ENSMUST00000114050.8
    Conserved Domains (1) summary
    pfam01290
    Location:3 → 41
    Thymosin; Thymosin beta-4 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72934330..72935731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZWY8.3 GenPept UniProtKB/Swiss-Prot:Q6ZWY8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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